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Product Name Kv beta 2 Chinese Name 电压门控钾Channel proteinKVβ.2抗体 Alias AKR6A5; HKv beta 2; HKvbeta 2; HKvbeta2.1; HKvbeta2.2; K(+) channel subunit beta 2; K+ channel beta 2 subunit; KCNA2B; KCNAB 2; KCNAB2; KCNK2; Kv Beta 2; Kvbeta2; MGC117289; Potassium channel shaker chain beta 2; Potassium voltage gated channel shaker related subfamily; Potassium voltage gated channel shaker related subfamily beta member 2; Voltage gated potassium channel beta 2 subunit; Voltage gated potassium channel subunit beta 2; KCAB2_HUMAN; Voltage-gated potassium channel subunit beta-2; AltName: Full=K(+) channel subunit beta-2; AltName: Full=Kv-beta-2; hKvbeta2. Research Area Neurobiology Channel protein The cell membrane受体 Immunogen Species Rabbit Clonality Polyclonal React Species Rat, (predicted: Human, Mouse, Dog, Pig, Cow, Rabbit, Zebrafish, Sheep, ) Applications ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 41kDa Cellular localization cytoplasmic Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human KCNA2B/Kv beta 2: 251-350/367 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member is one of the beta subunits, which are auxiliary proteins associating with functional Kv-alpha subunits. This member alters functional properties of the KCNA4 gene product. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Dec 2010]
Function:
Voltage gated potassium (Kv) channels represent the most complex class of voltage gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence related potassium channel genes: shaker, shaw, shab, and shal, have been identified in Drosophila, and each has been shown to have human homolog(s). This protein belongs to the potassium channel, voltage gated, shaker related subfamily and is one of the beta subunits, which are auxiliary proteins associating with functional Kv alpha subunits. This member alters functional properties of the KCNA4 gene product. Alternative splicing of this gene results in two transcript variants encoding distinct isoforms.
Subunit:
Forms heteromultimeric complex with alpha subunits. Forms a ternary complex with SQSTM1 and PRKCZ (By similarity).
Subcellular Location:
Cytoplasmic
Post-translational modifications:
Phosphorylated by PRKCZ; may be regulated by incorporation in a complex composed of PRKCZ and SQSTM1 (By similarity).
Similarity:
Belongs to the shaker potassium channel beta subunit family.
SWISS:
Q13303
Gene ID:
8514
Database links:Entrez Gene: 8514 Human
Entrez Gene: 16498 Mouse
Omim: 601142 Human
SwissProt: Q13303 Human
SwissProt: P62482 Mouse
SwissProt: Q3UPV6 Mouse
SwissProt: q64284 Mouse
Unigene: 440497 Human
Unigene: 10757 Rat
Product Picture Tissue/cell: rat pancreas tissue; 4% Paraformaldehyde-fixed and paraffin-embedded;
Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min;
Incubation: Anti-Kv beta 2 Polyclonal Antibody, Unconjugated(SL12182R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining
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