Product Name	KCNF1
Chinese Name	电压门控性钾Channel protein亚基kv5.1抗体
Alias	IK 8; IK8; KCNF 1; KCNF; Kcnf1; KCNF1_HUMAN; kH 1; kH1; KV5.1; Potassium voltage-gated channel subfamily F member 1; MGC33316; Potassium channel KH1; Potassium channel Kv5.1; Potassium voltage gated channel subfamily F member 1; Potassium voltage-gated channel subfamily F member 1; Voltage gated potassium channel subunit Kv5.1; Voltage-gated potassium channel subunit Kv5.1.
literatures	Specific References  (1)     |     SL12173R has been referenced in 1 publications. [IF=4.43] Slaats et al. Screen-based identification and validation of four new ion channels as regulators of renal ciliogenesis. (2015) J.Cell.Sc. 128:4550-9  IF,WB ;  Mouse.   PubMed:26546361
Research Area	Tumour  Cell biology  Neurobiology  Signal transduction  Channel protein  The cell membrane受体
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Mouse,  (predicted: Human, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep, Guinea Pig, )
Applications	WB=1:500-2000 ELISA=1:5000-10000  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	56kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human KCNF1: 161-260/494 <Extracellular>
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	KCNF1 is a multi-pass membrane-bound protein that acts as an ion channel and is generally expressed as a heterotetramer of potassium channeling proteins. Formerly known as kH1, KCNF1 is usually found as a heteromer with three other potassium channel proteins, KCNG3, KV6.3 and KCNV2. As a potassium channel protein, KCNF1 plays a role in regulating apoptosis and proliferation of pulmonary artery smooth muscle (PASM) cells. Bone morphogenetic proteins (BMPs) restrict proliferation and can induce apoptosis in normal human PASM cells and will upregulate expression of KCNF1 in PASM cells in vitro. KCNF1 is expressed in heart, brain, liver, skeletal muscle, kidney and pancreas. Function: Putative voltage-gated potassium channel. Subunit: Heteromultimer with KCNG3, KCNG4 and KCNV2. Interacts with DLG1. Subcellular Location: Membrane. Tissue Specificity: Detected in heart, brain, liver, skeletal muscle, kidney and pancreas. Similarity: Belongs to the potassium channel family. F (TC 1.A.1.2) subfamily. Kv5.1/KCNF1 sub-subfamily. SWISS: Q9H3M0 Gene ID: 3754 Database links: Entrez Gene: 3754 Human Entrez Gene: 382571 Mouse Omim: 603787 Human SwissProt: Q9H3M0 Human SwissProt: Q7TSH7 Mouse Unigene: 23735 Human Unigene: 40173 Mouse
Product Picture	Sample: Liver (Mouse) Lysate at 40 ug Primary: Anti- KCNF1 (SL12173R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 56 kD Observed band size: 56 kD

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