Product Name	NAV3
Chinese Name	神经元引导蛋白3抗体
Alias	KIAA0938; NAV 3; NAV3; NAV3_HUMAN; Neuron navigator 3; POMFIL1; Pore membrane and/or filament-interacting-like protein 1; Steerin 3; Steerin-3; STEERIN3; Unc 53 homolog 3; Unc-53 homolog 3; unc53H3.
literatures	Specific References  (1)     |     SL12151R has been referenced in 1 publications. [IF=24.633] Yanxin Li. et al. Decoding the temporal and regional specification of microglia in the developing human brain. Cell Stem Cell. 2022 Mar;:  IF ;  Mouse,Human.   PubMed:35245443
Research Area	Cell biology  Neurobiology
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Mouse,  (predicted: Human, Rat, Chicken, Horse, Sheep, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	255kDa
Cellular localization	The nucleus The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human NAV3: 301-400/2385
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	May regulate IL2 production by T-cells. May be involved in neuron regeneration. Function: May regulate IL2 production by T-cells. May be involved in neuron regeneration. Subcellular Location: Nucleus outer membrane. Tissue Specificity: Highly expressed in brain. Expressed at low levels in heart and placenta. Present in activated T-cells but not in resting T-cells (at protein level). Down-regulated in primary neuroblastoma. DISEASE: Note=A chromosomal aberration disrupting NAV3 has been found in patients with Sezary syndrome. Translocation t(12;18)(q21;q21.2). Similarity: Sequence similarities; Belongs to the Nav/unc-53 family. Contains 1 CH (calponin-homology) domain. SWISS: Q8IVL0 Gene ID: 89795 Database links: Entrez Gene: 89795 Human Entrez Gene: 260315 Mouse Entrez Gene: 314814 Rat Omim: 611629 Human SwissProt: Q8IVL0 Human SwissProt: Q80TN7 Mouse Unigene: 655301 Human Unigene: 225050 Mouse Unigene: 394160 Mouse Unigene: 461280 Mouse
Product Picture	Sample: Cerebrum (Mouse) Lysate at 40 ug Primary: Anti- NAV3 (SL12151R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 255 kD Observed band size: 255 kD

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