Product Name	Striatin 3
Chinese Name	CyclinSG2N抗体
Alias	Striatin3; Striatin-3; Striatin 3; Cell cycle autoantigen SG2NA; Cell cycle S/G2 nuclear autoantigen; GS2NA; nuclear autoantigen; S/G2 antigen; SG2NA; Striatin 3; Striatin, calmodulin binding protein 3; STRN3_HUMAN.
Research Area	Cell biology  Neurobiology  Signal transduction  Cyclin  The cell membrane受体  Binding protein
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Mouse,  (predicted: Human, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, )
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	87kDa
Cellular localization	cytoplasmic The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human Striatin 3/SG2NA: 75-180/797
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Striatin, SG2NA, and zinedin, the three mammalian members of the striatin family, are multimodular, WD repeat and calmodulin-binding proteins. Zinedin and SG2NA share with striatin identical protein-protein interaction domains and the same overall domain structure. All three proteins are both cytosolic and membrane-bound and bind calmodulin in the presence of calcium. Striatin is a neuronal, intracellular protein strictly expressed in the somato-dendritic compartment, including spines and subsets of neurons, and is considered as a marker of neuronal polarity. Downregulation of striatin, which is expressed in a few subsets of neurons, impairs the growth of dendrites as well as rat locomotor activity. Zinedin is mainly expressed in the central nervous system, whereas SG2NA is mainly expressed in the brain and muscle. Function: Binds calmodulin in a calcium dependent manner. May function as scaffolding or signaling protein. Subunit: Interacts with protein phosphatase 2A (PP2A) (Potential). Subcellular Location: Cytoplasm. Membrane; Peripheral membrane protein. Similarity: Belongs to the WD repeat striatin family. Contains 6 WD repeats. SWISS: Q13033 Gene ID: 29966 Database links: Entrez Gene: 29966 Human Entrez Gene: 94186 Mouse Entrez Gene: 114520 Rat SwissProt: Q13033 Human SwissProt: Q9ERG2 Mouse SwissProt: P58405 Rat
Product Picture	Paraformaldehyde-fixed, paraffin embedded (Mouse brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (Striatin 3) Polyclonal Antibody, Unconjugated (SL12135R) at 1:500 overnight at 4°C, followed by a conjugated secondary (sp-0023) for 20 minutes and DAB staining.

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