Product Name	SCN7A
Chinese Name	钠离子Channel protein7α/Na+ CP type VIIα抗体
Alias	Putative voltage gated sodium channel subunit alpha Nax; SCN 6A; SCN 7A; SCN6A; Sodium channel protein cardiac and skeletal muscle subunit alpha; Sodium channel protein type 7 subunit alpha; Sodium channel protein type VII subunit alpha; Sodium channel voltage gated type VI alpha polypeptide; Sodium channel voltage gated type VII alpha; Sodium channel voltage gated type VII alpha polypeptide; Voltage dependent sodium channel alpha subunit; SCN7A_HUMAN.
Research Area	Neurobiology  Channel protein  The cell membrane受体
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Rat,  (predicted: Human, Mouse, Pig, Cow, Horse, Sheep, )
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	193kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human SCN7A: 1561-1582/1682
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Voltage-gated sodium channels are selective ion channels that regulate the permeability of sodium ions in excitable cells. During the propagation of an action potential, sodium channels allow an influx of sodium ions, which rapidly depolarize the cell. The three glycoproteins that comprise the voltage-gated sodium channel proteins include a pore-forming Beta subunit, a noncovalently associated Beta 1 subunit and a disulfide-linked Beta 2 subunit. Na+ CP type VII Alpha (Sodium channel protein type 7 subunit alpha), also known as SCN6A, Sodium channel protein cardiac and skeletal muscle subunit alpha and putative voltage-gated sodium channel subunit alpha Nax, is a 1682 amino acid multi-pass membrane protein that belongs to the sodium channel family. Primarily expressed in uterus and heart, Na+ CP type VII Alpha may function in the regulation of salt intake behavior and central sensing of body-fluid sodium levels. Function: Voltage dependent sodium channels mediate the sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, they form a sodium selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. These ion channel proteins exist as heteromultimeric complexes of a large alpha subunit and 1 or 2 smaller beta subunits. SCN7A (Sodium channel protein type 7 subunit alpha) is an alpha subunit and is expressed in heart and uterus. Subcellular Location: Membrane; Multipass membrane protein. Tissue Specificity: Heart and uterus. Similarity: Belongs to the sodium channel (TC 1.A.1.10) family. SCN7A subfamily. SWISS: Q01118 Gene ID: 6332 Database links: Entrez Gene: 6332 Human Entrez Gene: 20272 Mouse Entrez Gene: 64155 Rat Omim: 182392 Human SwissProt: Q01118 Human SwissProt: Q62467 Mouse SwissProt: P97706 Rat Unigene: 695947 Human
Product Picture	Paraformaldehyde-fixed, paraffin embedded (Rat brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (SCN7A) Polyclonal Antibody, Unconjugated (SL12127R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.

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