Product Name	P2RX7
Chinese Name	嘌呤受体P2X7抗体
Alias	ATP receptor; P2X purinoceptor 7; P2X7; P2Z receptor; Purinergic receptor; purinergic receptor P2X, ligand gated ion channel 7; P2RX7_HUMAN.
literatures	Specific References  (4)     |     SL12106R has been referenced in 4 publications. [IF=4.932] Zhi Lu. et al. Dioscin ameliorates diabetes cognitive dysfunction via adjusting P2X7R/NLRP3 signal. Int Immunopharmacol. 2021 Nov;:108314  WB,IF ;  Rat.   PubMed:34785142 [IF=2.88] Zhou, Ying, et al. "P2X7 receptor in spinal tuberculosis: Gene polymorphisms and protein levels in Chinese Han population." Infection, Genetics and Evolution (2017).  WB ;  Human.   PubMed:29158203 [IF=2.353] Hui Huang. et al. The potential of the P2X7 receptor as a therapeutic target in a sub-chronic PCP-induced rodent model of schizophrenia. J Chem Neuroanat. 2021 Jun;:101993  WB,IHC ;  Mouse.   PubMed:34147620 [IF=1.88] Peng, Kuang, et al. "P2X7R is involved in the progression of atherosclerosis by promoting NLRP3 inflammasome activation." International Journal of Molecular Medicine.  IHC-F ;  Human.   PubMed:25761252
Research Area	Neurobiology  Channel protein  The cell membrane受体
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human, Mouse,  (predicted: Rat, Dog, Pig, Horse, Rabbit, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	69kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human P2RX7: 115-160/595 <Extracellular>
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	The P2X receptor family is comprised of ligand-gated ion channels that allow for the increased permeability of calcium into the cell in response to extracellular ATP. The seven P2X receptors, P2X1-P2X7, form either homomeric or heteromeric channels or both. They are characterized by intracellular amino- and carboxy-termini. P2X receptors are expressed in a wide variety of tissues, including neurons, prostate, bladder, pancreas, colon, testis and ovary. The major function of the P2X receptors is to mediate synaptic transmissions between neurons and to other tissues via the binding of extracellular ATP, which acts as a neurotransmitter. The P2X receptors may be involved in the onset of necrosis or apoptosis after prolonged exposure to high concentrations of extracellular ATP. Function: The product P2RX7 belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and is responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Activation of this nuclear receptor by ATP in the cytoplasm may be a mechanism by which cellular activity can be coupled to changes in gene expression. Subunit: Functional P2XRs are organized as homomeric and heteromeric trimers. Interacts with LAMA3, ITGB2, ACTB, ACTN4, SVIL, MPP3, HSPA1, HSPCB, HSPA8, PIK230 and PTPRB. Subcellular Location: Cell membrane; Multi-pass membrane protein. Post-translational modifications: Phosphorylation results in its inactivation. ADP-ribosylation at Arg-125 is necessary and sufficient to activate P2RX7 and gate the channel (By similarity). Palmitoylation of several cysteines in the C-terminal cytoplasmic tail is required for efficient localization to cell surface. Similarity: Belongs to the P2X receptor family. SWISS: Q99572 Gene ID: 5027 Database links: Entrez Gene: 5027 Human Entrez Gene: 18439 Mouse Entrez Gene: 29665 Rat Omim: 602566 Human SwissProt: Q99572 Human SwissProt: Q9Z1M0 Mouse SwissProt: Q64663 Rat Unigene: 729169 Human Unigene: 42026 Mouse Unigene: 10510 Rat
Product Picture	Sample: Lane 1: Human U937 cell lysates Lane 2: Human U251 cell lysates Lane 3: Human SH-SY5Y cell lysates Primary: Anti-P2RX7 (SL12106R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 69 kDa Observed band size: 74 kDa

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