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Product Name Cyclin M3 Chinese Name 周期素M3抗体 Alias ACDP3; Ancient conserved domain containing protein 3; CNNM3; DKFZp434I1016; FLJ20018; Metal transporter CNNM3; CNNM3_HUMAN. Research Area Cell biology immunology Signal transduction Cyclin Channel protein The cell membrane蛋白 Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, Dog, ) Applications WB=1:500-2000 ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 76kDa Cellular localization cytoplasmic The cell membrane Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human Cyclin M3: 251-350/707 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail Cyclin M3 is a 707 amino acid multi-pass membrane protein that shares weak sequence similarity with cyclin proteins, yet displays no cyclin-like function in vivo. Though ubiquitously expressed, Cyclin M3 is found at highest levels in kidney, brain, spleen and heart. Cyclin M3 is localized to the nucleus where it is likely a metal transporter. Cyclin M3 contains two CBS domains, which appear to bind ligands with an adenosyl group such as AMP, ATP and S-AdoMet and may play a regulatory role in sensitizing proteins to adenosyl-carrying ligands. There are three isoforms of Cyclin M3 that are produced as a result of alternative splicing events.
Function:
Cyclin M3 is a probable metal transporter. There are three named isoforms.
Subcellular Location:
Integral to plasma membrane; Multi-pass membrane protein
Tissue Specificity:
Widely expressed. Expressed at higher level in heart and spleen.
Similarity:
Belongs to the ACDP family.
Contains 2 CBS domains.
Contains 1 DUF21 domain.
SWISS:
Q8NE01
Gene ID:
26505
Database links:Entrez Gene: 26505 Human
Entrez Gene: 94218 Mouse
Omim: 607804 Human
SwissProt: Q8NE01 Human
SwissProt: Q32NY4 Mouse
Unigene: 711617 Human
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