Product Name	5HT1D Receptor
Chinese Name	5-羟色胺受体1D抗体
Alias	SR-1D; 5 HT 1D alpha; 5 HT 1D; 5 HT1B; 5 HT1D; 5HT1D; 5 hydroxytryptamine (serotonin) receptor 1B; 5 hydroxytryptamine (serotonin) receptor 1D G protein coupled; 5 hydroxytryptamine 1B receptor (5 HT 1B) (Serotonin receptor) (5 HT 1D beta) (Serotonin 1D beta receptor) (S12); 5 hydroxytryptamine receptor 1D; HT1DA; HTR1D; HTR1D2; HTR1DA; HTRL; RDC4; S12; Serotonin receptor 1D; 5HT1D_HUMAN.
literatures	Specific References  (1)     |     SL12046R has been referenced in 1 publications. [IF=3.263] Gharishvandi F et al. Involvement of 5-HT1B/1D receptors in the inflammatory response and oxidative stress in intestinal ischemia/reperfusion in rats. Eur J Pharmacol . 2020 Sep 5;882:173265.  IHF ;  Rat.   PubMed:32574671
Research Area	Neurobiology  The cell membrane受体  G protein-coupled receptor  The new supersedes the old  G protein signal
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Mouse, Rat,  (predicted: Human, Rabbit, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	42kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human 5HT1D Receptor/SR-1D: 2-110/377 <Extracellular>
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	The members of the G-protein-coupled receptor family are distinguished by their slow transmitting response to ligand binding. These seven transmembrane proteins include the adrenergic, serotonin and dopamine receptors. The effect of the signaling molecule can be excitatory or inhibitory depending on the type of receptor to which it binds. b-adrenergic bound to adrenaline activates adenylyl cyclase, while a2-adrenergic receptor bound to adrenaline inhibits adenylyl cyclase. Like the a2-adrenergic receptor, serotonin receptor functions are also mediated by G proteins that inhibit the activity of adenylyl cyclase. The serotonin receptors have been classified into several categories, designated SR-1–7 (5HT1–7). Subtypes within the SR-1 group include SR-1A, -1B, -1D, -1E and -1F. Function: This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity. Subcellular Location: Cell membrane; Multi-pass membrane protein Similarity: Belongs to the G-protein coupled receptor 1 family. SWISS: P28221 Gene ID: 3352 Database links: Entrez Gene: 3352 Human Entrez Gene: 15552 Mouse Entrez Gene: 25323 Rat Omim: 182133 Human SwissProt: P28221 Human SwissProt: Q61224 Mouse SwissProt: P28565 Rat Unigene: 121482 Human Unigene: 40573 Mouse Unigene: 34834 Rat
Product Picture	Sample: Lane 1: Mouse Cerebrum tissue lysates Lane 2: Rat Spinal cord tissue lysates Primary: Anti-5HT1D Receptor (SL12046R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 42 kDa Observed band size: 46 kDa Paraformaldehyde-fixed, paraffin embedded (Mouse brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (5HT1D Receptor) Polyclonal Antibody, Unconjugated (SL12046R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.

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