Product Name	GNAL
Chinese Name	腺苷酸环化酶Gα蛋白/Gαs/olf抗体
Alias	Adenylate cyclase stimulating G alpha protein, olfactory type; Adenylate cyclase stimulating G alpha protein, olfactory type; Adenylate cyclase-stimulating G alpha protein; Gnal; GNAL_HUMAN; Guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type; Guanine nucleotide binding protein (G protein), alpha stimulating activity polypeptide, olfactory type; Guanine nucleotide binding protein G(olf) subunit alpha; Guanine nucleotide-binding protein G(olf) subunit alpha; olfactory type.
Research Area	Cell biology  Neurobiology  Signal transduction  G protein-coupled receptor  G protein signal
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Chicken, Pig, Cow, Rabbit, Sheep, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	44kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human GNAL: 21-130/381
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Heterotrimeric G proteins function to relay information from cell surface receptors to intracellular effectors (1). Each of a very broad range of receptors specifically detects an extracellular stimulus (a photon, pheromone, odorant, hormone or neurotransmitter) while the effectors (e.g., adenyl cyclase), which act to generate one or more intracellular messengers, are less numerous. In mammals, G protein alpha, beta and gamma polypeptides are encoded by at least 16, 4 and 7 genes, respectively (2-5). Most interest in G proteins has been focused on their alpha subunits, since these proteins bind and hydrolyze GTP and most obviously regulate the activity of the best studied effectors. More recent evidence, however, has established an important regulatory role for the beta gamma subunits (6-8). The Gs subfamily of G alpha subunits includes two closely related proteins, Ga s and Ga olf, which respectively stimulate adenylate cyclase and mediate response to olfactory stimuli (9). Function: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. G(olf) alpha mediates signal transduction within the olfactory neuroepithelium and the basal ganglia. May be involved in some aspect of visual transduction, and in mediating the effect of one or more hormones/neurotransmitters. Subunit: G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site. Tissue Specificity: Detected in olfactory neuroepithelium, brain, testis, and to a lower extent in retina, lung alveoli, spleen. Trace amounts where seen in kidney, adrenal gland and liver. Found to be expressed in all the insulinomas examined. Similarity: Belongs to the G-alpha family. G(s) subfamily. SWISS: P38405 Gene ID: 2774 Database links: Entrez Gene: 2774 Human Entrez Gene: 14680 Mouse Entrez Gene: 24611 Rat Omim: 139312 Human SwissProt: P38405 Human SwissProt: Q8CGK7 Mouse SwissProt: P38406 Rat

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