Product Name	PAX1
Chinese Name	配对盒基因1抗体
Alias	HUP48; OTTHUMP00000030407; Paired box 1; Paired box gene 1; Paired box protein Pax 1; Paired domain gene HuP48; PAX 1; PAX1_HUMAN.
Research Area	Tumour  Developmental biology  Signal transduction  Stem cells  transcriptional regulatory factor
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human, Mouse,  (predicted: Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, )
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	55kDa
Cellular localization	The nucleus
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human PAX1: 151-250/534
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	This gene is a member of the paired box (PAX) family of transcription factors. Members of the PAX family typically contain a paired box domain and a paired-type homeodomain. These genes play critical roles during fetal development. This gene plays a role in pattern formation during embryogenesis and may be essential for development of the vertebral column. This gene is silenced by methylation in ovarian and cervical cancers and may be a tumor suppressor gene. Mutations in this gene are also associated with vertebral malformations. [provided by RefSeq, Mar 2012] Function: This protein is a transcriptional activator. It may play a role in the formation of segmented structures of the embryo. May play an important role in the normal development of the vertebral column. Subcellular Location: Nucleus. Similarity: Contains 1 paired domain. SWISS: P15863 Gene ID: 5075 Database links: Entrez Gene: 5075 Human Entrez Gene: 18503 Mouse Entrez Gene: 311505 Rat Omim: 167411 Human SwissProt: P15863 Human SwissProt: P09084 Mouse Unigene: 349082 Human Unigene: 315502 Mouse 同源结构域蛋白（Homeodomain Proteins） PAX蛋白在器官发生中起关键作用，包括促进细胞增殖、细胞世系的特异化、迁移和存活。一些PAX基因在多种癌症类型中表达，因此可以作为有用的TumourMaker。

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