Product Name	Phospho-Serine/Threonine
Chinese Name	磷酸化丝氨酸/苏氨酸抗体
Alias	Phosphoserine/threonine; phospho-Ser/Phospho-Thr; pan phospho-Ser/Phospho-Thr; pan-phospho-Ser/Phospho-Thr; pS/pT; p-S/p-T; pSER/pThr; p-SER/p-Thr; p-Sp-T; pan pS/pT; pan p-S/p-T; pan pSER/pThr; pan p-SER/p-Thr; pan p-Sp-T..  泛磷酸化丝氨酸/苏氨酸抗体; 丝氨酸/苏氨酸泛磷酸化; pan 磷酸化丝氨酸/苏氨酸; pan-磷酸化丝氨酸/苏氨酸; 泛丝氨酸磷酸化; 泛苏氨酸磷酸化; 泛丝氨酸/苏氨酸磷酸化;
literatures	Specific References  (1)     |     SL11994R has been referenced in 1 publications. [IF=5.26] Li et al. MAD2L2 inhibits colorectal cancer growth by promoting NCOA3 ubiquitination and degradation. (2018) Mol.Oncol. 12:391-405  WB ;  Human.   PubMed:29360267
Product Type	Phosphorylated anti
Research Area	Tumour  Cell biology  Neurobiology  Signal transduction  Kinases and Phosphatases
Immunogen Species	Rabbit
Clonality	Polyclonal
Applications	IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Cellular localization	cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthesised phosphopeptide contain Phosphoserine and Phosphothreonine: (p-S)(p-T)-NH2
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	A hallmark of signal transduction pathways is the reversible phosphorylation of serine and threonine residues within specific sequences, or motifs, in target proteins. Specific signaling motifs include not only sequences that are recognized by protein kinases, but also those that are recognized by phosphorylation-dependent binding proteins like 14-3-3. These modular phosphoprotein interacting domains are critical elements in modulating, directing and amplifying intracellular communications. Many critical protein kinases can be regulated by phosphorylation at a specific serine or threonine surrounded by phenylalanine or tyrosine. For example, Akt, an important kinase that regulates cell survival, is activated by phosphorylation at Ser473, a site surrounded by phenylalanine and tyrosine. RSK1, p70 S6 K, and certain PKC isoforms also contain a similar consensus phosphorylation site. Phosphorylation of these sites is required for kinase activity. The Phospho-(Ser/Thr) Phe Antibody is a powerful tool for discovery of new proteins containing this important regulatory motif. SWISS: N/A Gene ID: 407-41-0
Product Picture	Paraformaldehyde-fixed, paraffin embedded (Human brain glioma); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (Phosphoserine,threonine) Polyclonal Antibody, Unconjugated (SL11994R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining. Paraformaldehyde-fixed, paraffin embedded (Rat brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (Phosphoserine,threonine) Polyclonal Antibody, Unconjugated (SL11994R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining. Paraformaldehyde-fixed, paraffin embedded (Mouse brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (Phosphoserine,threonine) Polyclonal Antibody, Unconjugated (SL11994R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.

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