Product Name	Gastrin
Chinese Name	胃泌素/蛙皮素抗体
Alias	Gastrin component II; Gastrin-34; Gastrin 34; Gastrin34; G34; Gastrin component III; Gastrin-17; Gastrin 17; Gastrin17; G17; GAS; GAST; Gastrin precursor; Bombesin; gastrin big; Gastrin-71; Gastrin 71; Gastrin71; Gastrin-52; Gastrin 52; Gastrin52; Big gastrin; Gastrin-14; Gastrin 14; Gastrin14; G14; Gastrin-6; Gastrin 6; Gastrin6; G6; Gastrin; Gastrin component I; G52; GAST_HUMAN.
literatures	Specific References  (2)     |     SL1189R has been referenced in 2 publications. [IF=38.637] Kenta Kawasaki. et al. An Organoid Biobank of Neuroendocrine Neoplasms Enables Genotype-Phenotype Mapping. Cell. 2020 Nov;183:1420  IHC ;  Human.   PubMed:33159857 [IF=0.392] Yildiz, M.. et al. The Effect of Chronic Intermittent Cold Exposure on Gastrin-, Somatostatin-, Secretin-, and Serotonin-Containing Cells in the Small Intestine of Rats. Biol Bull+. 2021 Dec;48(3):S95-S106  IHC ;  Rat.   PubMed:10.1134/S1062359022010174
Research Area	Growth factors and hormones
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Rat,  (predicted: Human, Mouse, Pig, Rabbit, )
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	2.1/3.9/6/8kDa
Cellular localization	Secretory protein
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human Gastrin: 77-92/101
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Gastrin is mainly known by its first described role as a gastric acid-hormone but the protein also has the ability to promote cellular growth. More recently, gastrin has been suggested to induce leukocyte-endothelial cell interactions and to have a pro-inflammatory effect. Gastrin has two biologically active peptide forms, G34 and G17 and they activate two different receptors: the CCK-1 receptor, which has low affinity for gastrin but high affinity for the related hormone cholecystokinin (CCK), and the CCK-2 receptor, which has high affinity for both gastrin and CCK and mediates the acid-secretory as well as the proliferative effects of gastrin. Function: Gastrin stimulates the stomach mucosa to produce and secrete hydrochloric acid and the pancreas to secrete its digestive enzymes. It also stimulates smooth muscle contraction and increases blood circulation and water secretion in the stomach and intestine. Subcellular Location: Secreted. Post-translational modifications: Two different processing pathways probably exist in antral G-cells. In the dominant pathway progastrin is cleaved at three sites resulting in two major bioactive gastrins, gastrin-34 and gastrin-17. In the putative alternative pathway, progastrin may be processed only at the most C-terminal dibasic site resulting in the synthesis of gastrin-71. Sulfation enhances proteolytic processing, and blocks peptide degradation. Levels of sulfation differ between proteolytically-cleaved gastrins. Thus, gastrin-6 is almost 73% sulfated, whereas the larger gastrins are less than 50% sulfated. Sulfation levels are also tissue-specific. Similarity: Belongs to the gastrin/cholecystokinin family. SWISS: P01350 Gene ID: 2520 Database links: Entrez Gene: 2520 Human Entrez Gene: 14459 Mouse Omim: 137250 Human SwissProt: P01350 Human SwissProt: P48757 Mouse Unigene: 2681 Human Gastrin又称蛙皮素（Bombesin），是一种含十七个氨基酸残基的多肽类激素。它是由胃黏膜产生，可刺激胃液、盐酸、及消化酶的分泌。Gastrin还可刺激平滑肌收缩、增加血液循环和胃肠道液体的分泌。
Product Picture	Paraformaldehyde-fixed, paraffin embedded (rat stomach ); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (Gastrin) Polyclonal Antibody, Unconjugated (SL1189R) at 1:200 overnight at 4°C, followed by a conjugated secondary (sp-0023) for 20 minutes and DAB staining.

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