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Product Name NETO2 Chinese Name 脑特异性Transmembrane protein抗体 Alias Brain specific transmembrane protein; Brain specific transmembrane protein containing 2 CUB and 1 LDL receptor class A domains protein 2; Brain-specific transmembrane protein containing 2 CUB and 1 LDL-receptor class A domains protein 2; BTCL2; FLJ10430; FLJ14724; FLJ90456; NEOT2; NETO 2; Neto2; NETO2_HUMAN; Neuropilin (NRP) and tolloid (TLL) like 2; Neuropilin and tolloid like protein 2; Neuropilin and tolloid-like protein 2. Research Area Neurobiology Channel protein The cell membrane蛋白 Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, Dog, Pig, Cow, Sheep, ) Applications ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 57kDa Cellular localization The cell membrane Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human NETO2: 151-250/525 <Extracellular> Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail This gene encodes a predicted transmembrane protein containing two extracellular CUB domains followed by a low-density lipoprotein class A (LDLa) domain. A similar gene in rats encodes a protein that modulates glutamate signaling in the brain by regulating kainate receptor function. Expression of this gene may be a biomarker for proliferating infantile hemangiomas. A pseudogene of this gene is located on the long arm of chromosome 8. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]
Function:
Accessory subunit of neuronal kainate-sensitive glutamate receptors, GRIK2 and GRIK3. Increases kainate-receptor channel activity, slowing the decay kinetics of the receptors, without affecting their expression at the cell surface, and increasing the open probability of the receptor channels. Modulates the agonist sensitivity of kainate receptors. Slows the decay of kainate receptor-mediated excitatory postsynaptic currents (EPSCs), thus directly influencing synaptic transmission.
Subunit:
Interacts with GRIK2 and GRIK3, but neither with AMPA-nor with NMDA-sensitive glutamate receptors
Subcellular Location:
Membrane.
Post-translational modifications:
N-glycosylated.
Similarity:
Contains 2 CUB domains.
Contains 1 LDL-receptor class A domain.
SWISS:
Q8NC67
Gene ID:
81831
Database links:Entrez Gene: 81831 Human
Entrez Gene: 74513 Mouse
Omim: 607974 Human
SwissProt: Q8NC67 Human
SwissProt: Q8BNJ6 Mouse
Unigene: 444046 Human
Unigene: 126079 Mouse
Unigene: 222298 Rat
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