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Product Name Myotrophin Chinese Name 颗粒Cell differentiation蛋白抗体 Alias FLJ31098; FLJ99857; GCDP; Granule cell differentiation protein; MTPN; MTPN_HUMAN; Myotrophin; Protein V 1; Protein V-1; V 1; MTPN_HUMAN. literatures Specific References (1) | SL11891R has been referenced in 1 publications.[IF=2.379] Jieting Liu. et al. Identification of robust diagnostic and prognostic gene signatures in different grades of gliomas: a retrospective study. Peerj. 2021 May;9:e11350 WB ; Human.Research Area Cardiovascular Cell biology Neurobiology Cell differentiation Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Sheep, ) Applications WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 13kDa Cellular localization The nucleus cytoplasmic Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from humam Myotrophin/GCDP: 41-118/118 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail The transcript produced from this gene is bi-cistronic and can encode both myotrophin and leucine zipper protein 6. The myotrophin protein is associated with cardiac hypertrophy, where it is involved in the conversion of NFkappa B p50-p65 heterodimers to p50-p50 and p65-p65 homodimers. This protein also has a potential function in cerebellar morphogenesis, and it may be involved in the differentiation of cerebellar neurons, particularly of granule cells. A cryptic ORF at the 3' end of this transcript uses a novel internal ribosome entry site and a non-AUG translation initiation codon to produce leucine zipper protein 6, a 6.4 kDa tumor antigen that is associated with myeloproliferative disease. [provided by RefSeq, Jul 2008]
Function:
Potential role in cerebellar morphogenesis. May function in differentiation of cerebellar neurons, particularly of granule cells. Seems to be associated with cardiac hypertrophy.
Subunit:
Interacts with RELA (By similarity). Interacts with the heterodimer formed by CAPZA1 and CAPZB.
Subcellular Location:
Cytoplasm (Probable). Nucleus (By similarity). Cytoplasm, perinuclear region (By similarity).
Tissue Specificity:
Ubiquitous.
Similarity:
Belongs to the myotrophin family.
Contains 3 ANK repeats.
SWISS:
P58546
Gene ID:
136319
Database links:Entrez Gene: 136319 Human
Entrez Gene: 14489 Mouse
Omim: 606484 Human
SwissProt: P58546 Human
SwissProt: P62774 Mouse
SwissProt: Q7T2B9 Zebrafish
Unigene: 602015 Human
Unigene: 182746 Mouse
Unigene: 3239 Rat
Unigene: 75187 Zebrafish
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