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Rabbit Anti-METRN antibody
Rabbit Anti-METRN antibody
C16orf23; c380A1.2; Meteorin; Meteorin precursor; meteorin, glial cell differentiation regulator; Metrn; METRN_HUMAN; MGC2601.
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  • NO.:SL11886R
    Clonality:Polyclonal
    Immunogen Species:Rabbit
    React Species:Mouse,(predicted: Human,Rat,Cow,)
    Applications:WB ELISA IHC-P IHC-F ICC IF
    concentration:1mg/ml
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Details

Product Name METRN
Chinese Name Meteorin神经胶质Cell differentiation调节蛋白抗体
Alias C16orf23; c380A1.2; Meteorin; Meteorin precursor; meteorin, glial cell differentiation regulator; Metrn; METRN_HUMAN; MGC2601.  
Research Area Developmental biology  Neurobiology  Cell differentiation  
Immunogen Species Rabbit
Clonality Polyclonal
React Species Mouse,  (predicted: Human, Rat, Cow, )
Applications WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight 29kDa
Cellular localization Secretory protein 
Form Liquid
Concentration 1mg/ml
immunogen KLH conjugated synthetic peptide derived from human METRN: 101-200/293 
Lsotype IgG
Purification affinity purified by Protein A
Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
Product Detail Meteorin is a secreted protein belonging to the Meteorin family that contains 293 amino acids and promotes axonal extension, axonal network formation and regulates glial cell differentiation. Expressed in radial glia and undifferentiated neural progenitors of the central and peripheral nervous system, Meteorin is encoded by a gene located on human chromosome 16, which encodes over 900 genes and comprises nearly 3% of the human genome. The GAN (Gigaxonin) gene is located on chromosome 16 and, with mutation, may lead to giant axonal neuropathy, a nervous system disorder characterized by increasing malfunction with growth. The rare disorder Rubinstein-Taybi syndrome is also associated with chromosome 16, as is Crohn's disease, which is a gastrointestinal inflammatory condition.

Function:
Involved in both glial cell differentiation and axonal network formation during neurogenesis. Promotes astrocyte differentiation and transforms cerebellar astrocytes into radial glia. Also induces axonal extension in small and intermediate neurons of sensory ganglia by activating nearby satellite glia.

Subcellular Location:
Secreted.

Similarity:
Belongs to the meteorin family.

SWISS:
Q9UJH8

Gene ID:
79006

Database links:

Entrez Gene: 79006 Human

Entrez Gene: 70083 Mouse

Entrez Gene: 287151 Rat

Omim: 610998 Human

SwissProt: Q9UJH8 Human

SwissProt: Q8C1Q4 Mouse

SwissProt: Q5Q0T9 Rat



Product Picture
Sample:
Cerebellum (Mouse) Lysate at 40 ug
Cerebrum (Mouse) Lysate at 40 ug
Primary: Anti- METRN (SL11886R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 29 kD
Observed band size: 29 kD

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