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Product Name METRN Chinese Name Meteorin神经胶质Cell differentiation调节蛋白抗体 Alias C16orf23; c380A1.2; Meteorin; Meteorin precursor; meteorin, glial cell differentiation regulator; Metrn; METRN_HUMAN; MGC2601. Research Area Developmental biology Neurobiology Cell differentiation Immunogen Species Rabbit Clonality Polyclonal React Species Mouse, (predicted: Human, Rat, Cow, ) Applications WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 29kDa Cellular localization Secretory protein Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human METRN: 101-200/293 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail Meteorin is a secreted protein belonging to the Meteorin family that contains 293 amino acids and promotes axonal extension, axonal network formation and regulates glial cell differentiation. Expressed in radial glia and undifferentiated neural progenitors of the central and peripheral nervous system, Meteorin is encoded by a gene located on human chromosome 16, which encodes over 900 genes and comprises nearly 3% of the human genome. The GAN (Gigaxonin) gene is located on chromosome 16 and, with mutation, may lead to giant axonal neuropathy, a nervous system disorder characterized by increasing malfunction with growth. The rare disorder Rubinstein-Taybi syndrome is also associated with chromosome 16, as is Crohn's disease, which is a gastrointestinal inflammatory condition.
Function:
Involved in both glial cell differentiation and axonal network formation during neurogenesis. Promotes astrocyte differentiation and transforms cerebellar astrocytes into radial glia. Also induces axonal extension in small and intermediate neurons of sensory ganglia by activating nearby satellite glia.
Subcellular Location:
Secreted.
Similarity:
Belongs to the meteorin family.
SWISS:
Q9UJH8
Gene ID:
79006
Database links:Entrez Gene: 79006 Human
Entrez Gene: 70083 Mouse
Omim: 610998 Human
SwissProt: Q9UJH8 Human
SwissProt: Q8C1Q4 Mouse
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