Product Name	NEUROD6
Chinese Name	神经Cell differentiation因子6抗体
Alias	MATH2/NEUROD6; MATH2 / NEUROD6; Atoh 2; Atoh2; Atonal homolog 2; Atonal protein homolog 2; Atonal protein homolog2; bHLH a2 antibodybHLHa 2; bHLHa2; Class A basic helix-loop-helix protein 2; Helix loop helix protein mATH 2; Helix loop helix protein mATH2; MATH 2; Math2; NDF 6; NDF6; NDF6_HUMAN; Neuro D6; NeuroD6; Neurogenic differentiation 6; Neurogenic differentiation factor 6; Nex 1 antibodyNex 1m; Nex; Nex1; Nex1 m; Nex1m; Protein atonal homolog 2; Protein atonal homolog2.
Research Area	Cell biology  Neurobiology  Cell differentiation  Epigenetics
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Cow, Monkey, )
Applications	WB=1:500-2000 ELISA=1:5000-10000  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	38kDa
Cellular localization	The nucleus
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human MATH2/NEUROD6: 31-130/337
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	The Drosophila atonal gene produces a protein with basic helix loop helix (bHLH) domains that plays an essential role in the development of the Drosophila nervous system. Mammalian atonal homolog 2 (MATH-2) is a helix-loop-helix (HLH) transcription factor that is structurally homologous to the product of Drosophila atonal gene. MATH-2 is a 337 amino acid protein with an atonal-related basic HLH domain. In mice, expression of MATH-2 takes place by embryonic day 11.5 and initially localizes to the wall of brain vesicles and in the spinal cord. It is expressed in the cortical plate and the mantle layer in the developing central nervous system, and is limited to the nervous system in adults. Adult mouse cerebrums produce a high level of MATH-2 RNA with lower levels in other neuronal tissues. Research studies suggest that MATH-2 may function as a trans-acting factor involved in the development and maintenance of the mammalian nervous system. Function: Activates E box-dependent transcription in collaboration with TCF3/E47. May be a trans-acting factor involved in the development and maintenance of the mammalian nervous system. Transactivates the promoter of its own gene. Subunit: Efficient DNA binding requires dimerization with another bHLH protein Subcellular Location: Nucleus. Similarity: Contains 1 basic helix-loop-helix (bHLH) domain. SWISS: Q96NK8 Gene ID: 63974 Database links: Entrez Gene: 63974 Human Entrez Gene: 11922 Mouse Entrez Gene: 500137 Rat Entrez Gene: 540464 Cow Omim: 611513 Human SwissProt: Q08DI0 Cow SwissProt: Q96NK8 Human SwissProt: P48986 Mouse Unigene: 45152 Human Unigene: 5106 Mouse

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