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Product Name Lhx4 Chinese Name Lhx4蛋白抗体 Alias Gsh 4; Gsh4; Lhx4; LHX4_HUMAN; LIM Homeobox 4; LIM homeobox protein 4; LIM/homeobox protein Lhx4. Research Area Cell biology Neurobiology Signal transduction Zinc finger protein Epigenetics Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep, Guinea Pig, ) Applications WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 43kDa Cellular localization The nucleus Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human Lhx4: 171-280/390 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail The LIM domain (a zinc finger structure) is a protein-protein interaction motif found in several protein types, including homeodomain transcription factors and kinases, which has a role in many cellular processes. The LIM family of homeodomain proteins plays a role in organismal differentiation and development. Specifically, LHX4 and closely related LHX3 play essential roles in multiple developmental stages of the pituitary gland in mice. The LHX4 gene is expressed in murine fetal brain, spinal cord and cerebral cortex. In addition, LHX4 is expressed in the cerebral cortex and in the motor neurons of the CNS in adult rodents. A specific murine LHX4 gene mutation results in a short stature phenotype, pituitary and cerebelllar defects and sella turcica malformations. The LHX4 gene may be implicated in the t(1;4)(q25;q32) chromosomal translocation, which is associated with acute lymphoblastic leukemia. The LHX4 gene is also expressed in leukemic cells and may activate leukemogenesis. The human LHX4 gene maps to chromosome 1q25 and encodes a 390 amino acid protein.
Function:
May play a critical role in the development of respiratory control mechanisms and in the normal growth and maturation of the lung.
Subcellular Location:
Nucleus.
DISEASE:
Defects in LHX4 are the cause of pituitary hormone deficiency combined type 4 (CPHD4) [MIM:262700]; also known as short stature pituitary and cerebellar defects and small sella turcica. The disorder is characterized by short stature, pituitary and cerebellar defects, and small transverse depression crossing the midline on the superior surface of the body of the sphenoid bone which houses the pituitary gland.
Similarity:
Contains 1 homeobox DNA-binding domain.
Contains 2 LIM zinc-binding domains.
SWISS:
Q969G2
Gene ID:
89884
Database links:Entrez Gene: 89884 Human
Entrez Gene: 16872 Mouse
Omim: 602146 Human
SwissProt: Q969G2 Human
SwissProt: P53776 Mouse
Unigene: 658487 Human
Unigene: 103624 Mouse
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