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Product Name TMEM176B Chinese Name Transmembrane proteinTMEM176B抗体 Alias LR 8; LR8; TMEM176B; Transmembrane protein 176B; T176B_HUMAN. Research Area Cell biology Neurobiology The cell membrane蛋白 Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, ) Applications ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 29kDa Cellular localization The nucleus The cell membrane Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human LR8/TMEM176B: 25-150/270 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail Chromosome 7 is about 158 milllion bases long, encodes over 1000 genes and makes up about 5% of the human genome. Chromosome 7 has been linked to Osteogenesis imperfecta, Pendred syndrome, Lissencephaly, Citrullinemia and Shwachman-Diamond syndrome. The deletion of a portion of the q arm of chromosome 7 is associated with Williams-Beuren syndrome, a condition characterized by mild mental retardation, an unusual comfort and friendliness with strangers and an elfin appearance. Deletions of portions of the q arm of chromosome 7 are also seen in a number of myeloid disorders including cases of acute myelogenous leukemia and myelodysplasia. The LR8 gene product has been provisionally designated LR8 pending further characterization.
Function:
LR8 may be involved in the control of dendritic cell maturation and thus may play a role in the induction or maintenance of allograft tolerance. It's function is unknown.
Subcellular Location:
Nuclear membrane; Multi pass membrane protein.
Tissue Specificity:
Expressed in lung and dermal fibroblasts.
Similarity:
Belongs to the TMEM176 family.
SWISS:
Q3YBM2
Gene ID:
28959
Database links:Entrez Gene: 28959 Human
Omim: 610385 Human
SwissProt: Q3YBM2 Human
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