Product Name	LHX5
Chinese Name	LHX5蛋白抗体
Alias	LHX 5; Lhx5; LHX5_HUMAN; LIM homeobox 5; LIM homeobox protein 5; LIM/homeobox protein Lhx5; MGC129689.
Research Area	Cell biology  Neurobiology  Cell differentiation  Epigenetics
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Pig, Cow, Horse, Rabbit, Sheep, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	44kDa
Cellular localization	The nucleus
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human LHX5: 25-130/402
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	During development, genetically distinct subtypes of motor neurons express unique combinations of LIM-type homeodomain factors, which regulate cell migration and guide motor axons to establish the fidelity of a binary choice in axonal trajectory. The LIM gene family encodes a set of gene products, which carry the LIM domain, a unique cysteine-rich zinc-binding domain. At least 40 members of this family have been identified in vertebrates and invertebrates, and are distributed into 4 groups according to the number of LIM domains and to the presence of homeodomains and kinase domains. The human LHX5 gene maps to chromosome 12q23-q24 and encodes a 402 amino acid protein. The hippocampus contains the neural circuitry, which is crucial for cognitive functions such as learning and memory. LHX5 regulates precursor cell proliferation and neuronal differentiation and migration during hippocampal development. Function: Plays an essential role in the regulation of neuronal differentiation and migration during development of the central nervous system. Subcellular Location: Nucleus. Tissue Specificity: Expressed in fetal brain and in various regions of the adult central nervous system including the spinal cord, the thalamus, and the cerebellum. Similarity: Contains 1 homeobox DNA-binding domain. Contains 2 LIM zinc-binding domains. SWISS: Q9H2C1 Gene ID: 64211 Database links: Entrez Gene: 520759 Cow Entrez Gene: 64211 Human Entrez Gene: 16873 Mouse Entrez Gene: 124451 Rat Entrez Gene: 399270 Xenopus laevis Entrez Gene: 30465 Zebrafish Omim: 605992 Human SwissProt: Q9H2C1 Human SwissProt: P61375 Mouse SwissProt: P61376 Rat SwissProt: P37137 Xenopus laevis SwissProt: P52889 Zebrafish

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