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Product Name KLF7 Chinese Name KLF样转录因子7抗体 Alias KLF7; KLF7_HUMAN; Krueppel like factor 7; Krueppel-like factor 7; Kruppel like factor 7 ; Ubiquitous krueppel like factor; Ubiquitous krueppel-like factor; UKLF. Research Area Cell biology Signal transduction Cyclin transcriptional regulatory factor Cell differentiation Epigenetics Immunogen Species Rabbit Clonality Polyclonal React Species Mouse, (predicted: Human, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep, ) Applications WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 33kDa Cellular localization The nucleus Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human KLF7: 131-210/302 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail KLF7 is a transcriptional activator that belongs to the Krüppel C2H2-type zinc finger protein family. KLF7 targets promotor regions bearing CACCC elements in order to regulate transcription. It is believed that KLF7 is an important element for regulation of differentiation and the development of nervous systems. Specifically, increased expression of KLF7 is associated with neuronal precursors exiting the cell cycle and beginning to differentiate. Overexpression of KLF7 can lead to cell cycle arrest and a decrease in DNA synthesis. Also, KLF7 is thought to regulate the expression of Trk A, the receptor for nerve growth factor, which is required for the normal growth and maturation of neurons. KLF7 is a widely expressed protein with highest expression found in brain and nervous tissue.
Function:
Transcriptional activator. Binds in vitro to the CACCC motif of the beta-globin promoter and to the SP1 recognition sequence.
Subcellular Location:
Nucleus.
Tissue Specificity:
Ubiquitous and highly expressed in brain and spinal cord in the adult, and in kidney and brain in the embryo.
Similarity:
Belongs to the krueppel C2H2-type zinc-finger protein family.
Contains 3 C2H2-type zinc fingers.
SWISS:
O75840
Gene ID:
8609
Database links:Entrez Gene: 8609 Human
Entrez Gene: 93691 Mouse
Omim: 604865 Human
SwissProt: O75840 Human
SwissProt: Q99JB0 Mouse
Unigene: 471221 Human
Unigene: 29466 Mouse
Unigene: 458200 Mouse
Unigene: 102325 Rat
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