Product Name	Jarid2
Chinese Name	组蛋白去甲基化酶JARID2抗体
Alias	Jumonji; JARD2; JARD2_HUMAN; JARID2; JMJ; Jumonji AT rich interactive domain 2; Jumonji protein ; Jumonji/ARID domain containing protein 2; Jumonji/ARID domain-containing protein 2 ; Protein Jumonji.
literatures	Specific References  (2)     |     SL11860R has been referenced in 2 publications. [IF=2.089] Yiran Gu. et al. JARID2 regulates epithelial mesenchymal transition through the PTEN/AKT signalling pathways in ovarian endometriosis. REPROD BIOL. 2023 Mar;23:100729  IHC,WB ;  Human.   PubMed:36640627 [IF=1.768] Yoshinobu Ichikawa. et al. Egg Development After In Vitro Insemination in Japanese Quail (Coturnix japonica). J POULT SCI. 2023 Jan;60(1):2023001  WB ;  Coturnix japonica.   PubMed:36756046
Research Area	Tumour  Cell biology  Neurobiology  Signal transduction  transcriptional regulatory factor  Epigenetics
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human, Rat,  (predicted: Mouse, Chicken, Dog, Pig, Cow, Horse, Sheep, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	139kDa
Cellular localization	The nucleus
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human Jarid2/Jumonji: 301-400/1246
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	This gene encodes a Jumonji- and AT-rich interaction domain (ARID)-domain-containing protein. The encoded protein is a DNA-binding protein that functions as a transcriptional repressor. This protein interacts with the Polycomb repressive complex 2 (PRC2) which plays an essential role in regulating gene expression during embryonic development. This protein facilitates the recruitment of the PRC2 complex to target genes. Alternate splicing results in multiple transcript variants. Mutations in this gene are associated with chronic myeloid malignancies. [provided by RefSeq, May 2012] Function: Regulator of histone methyltransferase complexes that plays an essential role in embryonic development, including heart and liver development, neural tube fusion process and hematopoiesis. Acts by modulating histone methyltransferase activity and promoting the recruitment of histone methyltransferase complexes to their target genes. Binds DNA and mediates the recruitment of the PRC2 complex to target genes in embryonic stem cells. Does not have histone demethylase activity but regulates activity of various histone methyltransferase complexes. In embryonic stem cells, it associates with the PRC2 complex and inhibits trimethylation of 'Lys-27' of histone H3 (H3K27me3) by the PRC2 complex, thereby playing a key role in differentiation of embryonic stem cells and normal development. In cardiac cells, it is required to repress expression of cyclin-D1 (CCND1) by activating methylation of 'Lys-9' of histone H3 (H3K9me) by the GLP1/EHMT1 and G9a/EHMT2 histone methyltransferases. Also acts as a transcriptional repressor of ANF via its interaction with GATA4 and NKX2-5. Participates in the negative regulation of cell proliferation signaling. Subunit: Associates with a histone methyltransferase complex containing GLP1/EHMT1 and G9a/EHMT2. Interacts with SUZ12; the interaction is direct. Interacts with GATA4 (via the N-terminal region). Interacts with NKX2-5 (via the C-terminal region). Interacts with RB1. Interacts with ZNF496 (By similarity). Associates with the PRC2 complex, which includes EED, EZH1, EZH2, SUZ12, RBBP4 and AEBP2; JARID2 is probably not a core component of the PRC2 complex and associates to PRC2 via its interaction with SUZ12. Subcellular Location: Nucleus. Colocalizes with the PRC2 complex on chromatin. Tissue Specificity: During embryogenesis, predominantly expressed in neurons and particularly in dorsal root ganglion cells. Similarity: Contains 1 ARID domain. Contains 1 JmjC domain. Contains 1 JmjN domain. SWISS: Q92833 Gene ID: 3720 Database links: Entrez Gene: 3720 Human Entrez Gene: 16468 Mouse Omim: 601594 Human SwissProt: Q92833 Human SwissProt: Q62315 Mouse Unigene: 269059 Human Unigene: 25059 Mouse
Product Picture	Sample: Molt-4(Human) Cell Lysate at 30 ug K562(Human) Cell Lysate at 30 ug Primary: Anti- Jarid2 (SL11860R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 139 kD Observed band size: 139 kD Tissue/cell: rat brain tissue; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; Incubation: Anti-Jarid2/Jumonji Polyclonal Antibody, Unconjugated(SL11860R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining

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