Product Name	HELT
Chinese Name	转录因子HELT蛋白抗体
Alias	Hairy and enhancer of split-related protein HELT; HCM1228; HELT; HELT_HUMAN; HES like ; HES/HEY like transcription factor; HES/HEY-like transcription factor; HESL; Heslike ; Hey like transcription factor; Hey like transcription factor (zebrafish); Hey like transcriptional repressor; Megane bHLH factor; Mgn.
Research Area	Cell biology  Developmental biology  Neurobiology  Signal transduction  Stem cells  transcriptional regulatory factor
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Cow, Horse, Rabbit, Zebrafish, Sheep, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	36kDa
Cellular localization	The nucleus
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human HELT: 156-220/327
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	The Drosophila hairy and Enhancer of split genes encode basic helix-loop-helix (bHLH) transcriptional repressors that function in the Notch signaling pathway and control segmentation and neural development during embryogenesis. The Notch signaling pathway is thought to maintain stem cells through transcriptional activation of HES/HEY family members to repress tissue-specific transcription factors. HESL (HES-like), also known as Mgn or HELT (HES/HEY-like transcription factor), is a 327 amino acid nuclear protein belonging to the HEY family. Containing a basic helix-loop-helix (bHLH) domain and an Orange domain, HESL self-associates and interacts with HES5 and HRT2. HESL is considered a transcriptional repressor that binds to the canonical E box sequence 5'-CACGCG-3'. HESL exists as two isoforms produced by alternative splicing events. Function: Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGCG-3'. Subunit: Self-associates. Interacts with HES5 and HEY2 Subcellular Location: Nucleus. Similarity: Belongs to the HEY family. Contains 1 basic helix-loop-helix (bHLH) domain. Contains 1 Orange domain. SWISS: A6NFD8 Gene ID: 391723 Database links: Entrez Gene: 391723 Human Entrez Gene: 234219 Mouse Entrez Gene: 498633 Rat Entrez Gene: 404275 Zebrafish SwissProt: A6NFD8 Human SwissProt: Q7TS99 Mouse SwissProt: Q6QB00 Zebrafish Unigene: 531242 Human Unigene: 145631 Mouse Unigene: 91513 Zebrafish

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