Product Name	CSDC2
Chinese Name	冷休克结构域蛋白C2抗体
Alias	Cold shock domain containing C2 RNA binding; Cold shock domain containing protein C2; Cold shock domain-containing protein C2; CSDC 2; Csdc2; CSDC2_HUMAN; dJ347H13.2; PIPPIN; RNA binding protein PIPPin; RNA-binding protein PIPPin.
Research Area	Cell biology  Neurobiology  Signal transduction  Epigenetics
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Chicken, Pig, Cow, Horse, Rabbit, Sheep, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	17kDa
Cellular localization	The nucleus cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human PIPPIN: 21-120/153
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	PIPPIN is a Y-box protein (also called cold-shock (CSD) domain-containing protein) and belongs to a family of highly conserved RNA-binding transcriptional regulators. Predominantly expressed in brain cells and localizing to the nucleus and the cytoplasm, PIPPIN contains two RNA-binding motifs, namely PIP1 and PIP2, and one CSD domain. PIPPIN functions as a nucleic acid binding regulatory factor and is believed to participate in brain maturation. More specifically, PIPPIN binds to the 3’-UTR ends of the mRNAs encoding Histone H1 and Histone H3.3. This interaction requires all of the PIPPIN domains to work in concert as one functional protein. In addition, PIPPIN can be sumoylated in a thyroid hormone (T3)-dependent manner. This suggests that PIPPIN modification in response to extracellular stimuli may modulate the regulation of protein synthesis. Function: RNA-binding factor which binds specifically to the very 3'-UTR ends of both histone H1 and H3.3 mRNAs, encompassing the polyadenylation signal. Might play a central role in the negative regulation of histone variant synthesis in the developing brain. Subcellular Location: Nucleus. Cytoplasm. PIPPin-RNA complexes are located to the nucleus. Similarity: Contains 1 CSD (cold-shock) domain. SWISS: Q9Y534 Gene ID: 27254 Database links: Entrez Gene: 27254 Human Entrez Gene: 105859 Mouse Entrez Gene: 266600 Rat SwissProt: Q9Y534 Human SwissProt: Q91YQ3 Mouse SwissProt: Q63430 Rat Unigene: 310893 Human Unigene: 22524 Mouse Unigene: 1171 Rat

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