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Product Name GPR10 Chinese Name G protein-coupled receptor10抗体 Alias G protein coupled receptor 10; G-protein coupled receptor 10; GPR 10; GPR10; GCPR 10; GR 3; GR3; hGR 3; hGR3; MGC126539; MGC126541; PRLH RECEPTOR; PRLHR; PRLHR_HUMAN; Prolactin releasing hormone receptor; Prolactin releasing peptide receptor; Prolactin-releasing peptide receptor; PrRP receptor; PrRPR; uhr-1. Research Area Neurobiology Signal transduction G protein-coupled receptor G protein signal Immunogen Species Rabbit Clonality Polyclonal React Species Mouse, (predicted: Human, Rat, Dog, Pig, Cow, Sheep, Monkey, ) Applications WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 41kDa Cellular localization The cell membrane Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human GPR10 protein: 161-260/370 <Extracellular> Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail G protein-coupled receptors (GPRs or GPCRs), also known as seven transmembrane receptors, heptahelical receptors, or 7TM receptors, are members of the largest protein family and play a role in many different stimulus-response pathways. G-protein coupled receptors mediate extracellular signals into intracellular signals (G-protein activation). They respond to a great variety of signaling molecules, including hormones, neurotransmitters and other proteins and peptides. GPR proteins are integral seven-pass membrane proteins with some conserved amino acid regions. G-protein coupled receptor 10 (GPR10) acts as a receptor for prolactin-releasing peptide (PrRP). GPR10 plays a role in the regulation of food intake, pain-signal processing and lactation. Primarily expressed in pituitary gland, it is repressed by bromocriptine. GPR10 interacts with various other proteins, including GRIP1, GRIP2 and PICK1.
Function:
Receptor for prolactin-releasing peptide (PrRP). Implicated in lactation, regulation of food intake and pain-signal processing.
Subunit:
Interacts through its C-terminal region with the PDZ domain-containing proteins GRIP1, GRIP2 and PICK1. Interacts with PDZ domains 4 and 5 of GRIP1 and with the PDZ domain of PICK1.
Subcellular Location:
Cell membrane; Multi-pass membrane protein.
Tissue Specificity:
Only detected in the pituitary gland and in all cell types of pituitary adenomas.
Similarity:
Belongs to the G-protein coupled receptor 1 family.
SWISS:
P49683
Gene ID:
2834
Database links:
Entrez Gene: 2834 Human
Entrez Gene: 100412185 Marmoset (common)
Entrez Gene: 226278 Mouse
Omim: 600895 Human
SwissProt: P49683 Human
SwissProt: Q6VMN6 Mouse
Unigene: 248119 Human
Unigene: 377241 Mouse
Unigene: 138127 Rat
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