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Rabbit Anti-TAS2R49 antibody
Rabbit Anti-TAS2R49 antibody
T2R20; T2R20_HUMAN; T2R49; T2R56; TAS2R20; Taste receptor type 2 member 20; Taste receptor type 2 member 49; Taste receptor type 2 member 56
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Details

Product Name TAS2R49
Chinese Name 味觉2型受体蛋白家族49抗体
Alias T2R20; T2R20_HUMAN; T2R49; T2R56; TAS2R20; Taste receptor type 2 member 20; Taste receptor type 2 member 49; Taste receptor type 2 member 56  
Research Area Cell biology  Neurobiology  Signal transduction  Channel protein  The cell membrane受体  G protein-coupled receptor  G protein signal  The cell membrane蛋白  
Immunogen Species Rabbit
Clonality Polyclonal
React Species (predicted: Human, )
Applications WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight 35kDa
Cellular localization The cell membrane 
Form Liquid
Concentration 1mg/ml
immunogen KLH conjugated synthetic peptide derived from human TAS2R49: 111-210/309 <Extracellular>
Lsotype IgG
Purification affinity purified by Protein A
Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
Product Detail The sense of taste provides animals with valuable information about the quality and nutritional value of food. A family of G protein coupled receptors are involved in taste perception and include T1R, which is involved in sweet and umami taste perception and T2R, which is involved in bitter taste perception. Both types of taste receptors couple to various G proteins to initiate signal transduction cascades. T2R49 plays a role in sensing the chemical composition of the gastrointestinal content. T2R49 is expressed in subsets of taste receptor cells of the tongue and exclusively in gustducin-positive cells.

Function:
Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5.

Subcellular Location:
Membrane; Multi-pass membrane protein.

Tissue Specificity:
Expressed in subsets of taste receptor cells of the tongue and exclusively in gustducin-positive cells.

Similarity:
Belongs to the G-protein coupled receptor T2R family.

SWISS:
P59543

Gene ID:
259295

Database links:

Entrez Gene: 493898 Chimpanzee

Entrez Gene: 259295 Human

Omim: 613962 Human

SwissProt: Q646G1 Baboon

SwissProt: Q646C2 Chimpanzee

SwissProt: Q646A0 Gorilla

SwissProt: P59543 Human

SwissProt: Q645V6 Orangutan

Unigene: 686384 Human



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