TEL: +86 571 56623320 EMAIL: [email protected]
Product Name IF3 Chinese Name Mitochondrion翻译起始因子3抗体 Alias Mitocondrial Translational Initiation Factor 3; DC38; IF 3; IF 3Mt; IF-3(Mt); IF-3Mt; IF3; IF3(mt); IF3M_HUMAN; IF3Mt; mitochondrial; Mt; MTIF3; Translation initiation factor IF 3, mitochondrial precursor; Translation initiation factor IF-3. Research Area Cell biology Neurobiology Epigenetics Alzheimer's Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, ) Applications ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 28kDa Cellular localization cytoplasmic Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human Mitocondrial Translational Initiation Factor 3: 121-220/278 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail IF3 is also known as MTIF3 (mitochondrial translational initiation factor 3), DC38, IF3(mt) or IF-3mt, and is a 278 amino acid protein that is localized to mitochondria. IF3 aids in the initiation of protein synthesis by binding the 28S ribosomal subunit, which is a protein synthesis initiation site. The 28S and 39S ribosomal structures are subunits of the 55S ribosome, whose formation is favored in the absence of IF3, because IF3 allows the subunits to remain in their free form. Altered forms of IF3 may affect IF3’s function, which could alter the availability of mitochondrial encoded proteins, leading to oxidative stress and possibly causing an increased susceptibility to Parkinson’s disease. Polymorphism of the gene encoding IF3 is thought to be associated with Parkinson’s disease.
Function:
IF-3 binds to the 28S ribosomal subunit and shifts the equilibrum between 55S ribosomes and their 39S and 28S subunits in favor of the free subunits, thus enhancing the availability of 28S subunits on which protein synthesis initiation begins.
Subcellular Location:
Mitochondrion.
Similarity:
Belongs to the IF-3 family.
SWISS:
Q9H2K0
Gene ID:
219402
Database links:Entrez Gene: 219402 Human
SwissProt: Q9H2K0 Human
Unigene: 534582 Human
Scan Wechat Qrcode