Product Name	TTBK2
Chinese Name	Tau微管蛋白激酶2抗体
Alias	TTBK2/SCA11 Tau tubulin kinase 2; Spinocerebellar ataxia 11; Tau tubulin kinase 2; Tau-tubulin kinase 2; TTBK; TTBK 2; TTBK1; TTBK2; TTBK2_HUMAN; TTK; KIAA0847; mKIAA0847; SCA11.
literatures	Specific References  (1)     |     SL11771R has been referenced in 1 publications. [IF=8.077] Wang Liying. et al. SARS-CoV-2 ORF10 impairs cilia by enhancing CUL2ZYG11B activity. J CELL BIOL. 2022 Jul;221(7):e202108015.  WB ;  Human.   PubMed:35674692
Research Area	Neurobiology  Signal transduction  Kinases and Phosphatases  Cytoskeleton  Extracellular matrix
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rabbit, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	137kDa
Cellular localization	The nucleus cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human TTBK2/SCA11: 1151-1244/1244
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	This gene encodes a serine-threonine kinase that putatively phosphorylates tau and tubulin proteins. Mutations in this gene cause spinocerebellar ataxia type 11 (SCA11); a neurodegenerative disease characterized by progressive ataxia and atrophy of the cerebellum and brainstem. [provided by RefSeq, Aug 2009]. Function: Serine/threonine kinase which is able to phosphorylate tau on serines. Subunit: Interacts with CEP164. DISEASE: Defects in TTBK2 are the cause of spinocerebellar ataxia type 11 (SCA11) [MIM:604432]. Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA11 is an autosomal dominant cerebellar ataxia (ADCA). It is a relatively benign, late-onset, slowly progressive neurologic disorder. Similarity: Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Contains 1 protein kinase domain. SWISS: Q6IQ55 Gene ID: 146057 Database links: Entrez Gene: 146057 Human Omim: 611695 Human SwissProt: Q6IQ55 Human Unigene: 646511 Human Unigene: 727864 Human

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