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Product Name Synaptotagmin-14 Chinese Name 突触Binding protein14抗体 Alias Synaptotagmin14; Synaptotagmin 14; SCAR11; Synaptotagmin XIV; Synaptotagmin-14; SYT14; SYT14_HUMAN; SytXIV. Research Area Cell biology Neurobiology Binding protein Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, Chicken, Pig, Cow, Horse, Rabbit, Sheep, ) Applications WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 62kDa Cellular localization cytoplasmic The cell membrane Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human Synaptotagmin-14: 477-555/555 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail Synaptotagmins are a large gene family of synaptic vesicle type III integral membrane proteins that function as regulators of both exocytosis and endocytosis and are involved in neurotransmitter secretion from small secretory vesicles. Synaptotagmin XIV, also known as SytXIV, is a 555 amino acid single-pass type III membrane protein belonging to the Synaptotagmin family. With the ability to form heterodimers, Synaptotagmin XIV mainly exists as a homodimer and contains two C2 domains, an N-terminal transmembrane domain and a putative fatty-acylation site. Synaptotagmin XIV is Ca2+-independent and may function in the trafficking and exocytosis of secretory vesicles to tissues outside the brain. Disruption of Synaptotagmin XIV may be affiliated with neurodevelopmental abnormalities. Synaptotagmin XIV exists as six alternatively spliced isoforms and is encoded by a gene on human chromosome 1q32.2.
Function:
May be involved in the trafficking and exocytosis of secretory vesicles in non-neuronal tissues. Is Ca(2+)-independent.
Subunit:
Homodimer. Can also form heterodimers
Subcellular Location:
Membrane; Single-pass type III membraneprotein. Note=Localized in perinuclear and submembranous regions.
Tissue Specificity:
Highly expressed in fetal and adult braintissue.
DISEASE:
Defects in SYT14 are the cause of spinocerebellar ataxiaautosomal recessive type 11 (SCAR11) [MIM:614229]. Spinocerebellarataxia is a clinically and genetically heterogeneous group ofcerebellar disorders. Patients show progressive incoordination ofgait and often poor coordination of hands, speech and eyemovements, due to degeneration of the cerebellum with variableinvolvement of the brainstem and spinal cord. SCAR11 is associatedwith psychomotor retardation.
Similarity:
Belongs to the synaptotagmin family. Contains 2 C2 domains.
SWISS:
Q8NB59
Gene ID:
255928
Database links:Entrez Gene: 255928 Human
Entrez Gene: 329324 Mouse
Omim: 610949 Human
SwissProt: Q8NB59 Human
SwissProt: Q7TN84 Mouse
Unigene: 658866 Human
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