Product Name	Nmnat1
Chinese Name	烟酰胺核苷酸腺苷转移酶1抗体
Alias	NaMN adenylyltransferase 1; Nicotinamide mononucleotide adenylyltransferase 1; nicotinamide nucleotide adenylyltransferase 1; nicotinate nucleotide adenylyltransferase 1; Nicotinate-nucleotide adenylyltransferase 1; NMN adenylyltransferase 1; NMNA1_HUMAN; Nmnat 1; Nmnat1; Nmnat-1; OTTHUMP00000001731; OTTHUMP00000001732; OTTHUMP00000035892; PNAT 1; PNAT1; pyridine nucleotide adenylyltransferase 1.
literatures	Specific References  (1)     |     SL11738R has been referenced in 1 publications. [IF=0.496] Chuanjiang He. et al. MiRNA-494 specifically inhibits SIRT3-mediated microglia activation in sepsis-associated encephalopathy. TRANSL CANCER RES. 2022 Jul; 11(7): 2299–2309  WB ;  Rat.   PubMed:35966295
Research Area	Tumour  Neurobiology  The new supersedes the old  Epigenetics
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Mouse,  (predicted: Human, Rat, Chicken, Dog, Cow, Rabbit, Sheep, )
Applications	WB=1:500-2000 ELISA=1:5000-10000  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	32kDa
Cellular localization	The nucleus
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human Nmnat1: 201-279/279
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Nicotinamide adenine dinucleotide (NMNAT) is an essential cofactor involved in fundamental processes in cell metabolism. NMNAT plays a key role in NAD(+) biosynthesis, catalysing the condensation of nicotinamide mononucleotide and ATP, and yielding NAD(+) and pyrophosphate. NMNAT appears to be a substrate of nuclear kinases and contains at least three potential phosphorylation sites. The interaction of NMNAT with nuclear proteins is likely to be modulated by phosphorylation. NMNAT is widely expressed with highest levels in skeletal muscle, heart, liver and kidney. Function: Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate with the same efficiency. Can use triazofurin monophosphate (TrMP) as substrate. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity, prefers NAD(+) and NAAD as substrates and degrades NADH, nicotinic acid adenine dinucleotide phosphate (NHD) and nicotinamide guanine dinucleotide (NGD) less effectively. Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NAADP(+). Protects against axonal degeneration following mechanical or toxic insults. Subunit: Homohexamer. Interacts with ADPRT/PARP1. Subcellular Location: Nucleus. Tissue Specificity: Widely expressed with highest levels in skeletal muscle, heart and kidney. Also expressed in the liver pancreas and placenta. Widely expressed throughout the brain. Similarity: Belongs to the eukaryotic NMN adenylyltransferase family. SWISS: Q9HAN9 Gene ID: 64802 Database links: Entrez Gene: 64802 Human Entrez Gene: 66454 Mouse Omim: 608700 Human SwissProt: Q9HAN9 Human SwissProt: Q9EPA7 Mouse Unigene: 633762 Human Unigene: 76062 Mouse
Product Picture	Sample: Kidney (Mouse) Lysate at 40 ug Primary: Anti-Nmnat1 (SL11738R) at 1/500 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 32 kD Observed band size: 32 kD Sample: Testis (Mouse) Lysate at 40 ug Primary: Anti-Nmnat1 (SL11738R) at 1/500 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 32 kD Observed band size: 32 kD

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