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Product Name FOS B Chinese Name FosB抗体 Alias FBJ murine osteosarcoma viral oncogene homolog B; FOS B; FOS-B; FBJ osteosarcoma oncogene B; fosB; G0/G1 switch regulatory protein 3; FosB; G0/G1 switch regulatory protein 3; G0S3; GOS3; GOS 3; GOS B; GOSB; MGC42291; Oncogene FOS B; Oncogene FOSB; Protein fos B; Protein fosB; DKFZp686C0818; FOSB_HUMAN. Research Area Tumour Cell biology immunology Chromatin and nuclear signals transcriptional regulatory factor Epigenetics Immunogen Species Rabbit Clonality Polyclonal React Species Rat, (predicted: Human, Mouse, Dog, Pig, Cow, Horse, Rabbit, Guinea Pig, ) Applications ELISA=1:5000-10000 IHC-P=1:100-500 ICC=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 36kDa Cellular localization The nucleus Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human FOS B: 191-290/338 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail Cellular oncogenes, or proto-oncogenes, play pivotal roles in cellular communication pathways that regulate normal growth, development and differentiation. The cellular oncogene families fos and jun encode nuclear proteins that can function as transcription factors. The fos family of nuclear oncogenes encode cFos, Fos B, (fos-related antigen) Fra 1, and Fra 2. Also named as DKFZp686C0818; FBJ murine osteosarcoma viral oncogene homolog B; FosB; G0/G1 switch regulatory protein 3; G0S3; GOS3; GOSB; MGC42291; Oncogene FOS B; Protein fosB.
Function:
FosB interacts with Jun proteins enhancing their DNA binding activity.
Subunit:
Heterodimer.
Subcellular Location:
Nucleus.
Similarity:
Belongs to the bZIP family. Fos subfamily.
Contains 1 bZIP (basic-leucine zipper) domain.
SWISS:
P53539
Gene ID:
2354
Database links:Entrez Gene: 2354 Human
Omim: 164772 Human
SwissProt: P53539 Human
Unigene: 590958 Human
transcriptional regulatory factor(Transcriptin Regulators)
FOS B属于转录因子AP-1家族;FosB是一种转录因子,表达后能在脑内维持数周甚至几个月。长期药物滥用能引起伏核内FosB表达稳定地增加,表明FosB的表达可能是药物成瘾的分子转换机制,是当今药物成瘾研究中最受重视的转录因子。Product Picture Paraformaldehyde-fixed, paraffin embedded (rat brain tissue); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (FOS B) Polyclonal Antibody, Unconjugated (SL1170R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
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