Product Name	CCR3
Chinese Name	细胞表面Chemokine受体3抗体
Alias	CCR-3; CC chemokine receptor 3; Chemokine (C-C motif) receptor 3; MIP-1 alpha receptor like-2; B chemokine receptor; b-chemokine receptor; C C chemokine receptor type 3; C C CKR 3; C-C chemokine receptor type 3; CC chemokine receptor type 3; CC CKR 3; CC R3; CCCKR3; CCR 3; CCR3; CCR3_HUMAN; CD 193; CD193 antigen; chemokine (C-C motif) receptor 3; Chemokine (CC) receptor 1 like 2; Chemokine CC motif receptor 3; Chemokine receptor 3; CK R3; CKR 3; CMKB R3; CMKBR 3; CMKBR1L2; CMKBR3; Eosinophil CC chemokine receptor 3; Eosinophil eotaxin receptor; Eotaxin receptor; Macrophage inflammatory protein 1 alpha receptor like 2; MGC102841; MIP1 Alpha RL2;Probable C-C chemokine receptor type 3; C-C CKR-3; CC-CKR-3; CCR-3; CKR3; Macrophage inflammatory protein 1-alpha receptor-like 2; MIP-1 alpha RL2; CD193.
literatures	Specific References  (1)     |     SL1167R has been referenced in 1 publications. [IF=8.079] Hua Chunting. et al. Human umbilical cord mesenchymal stem cell treatment alleviates symptoms in an atopic dermatitis-like mouse model. STEM CELL RES THER. 2023 Dec;14(1):1-14  IHC ;  Mouse.   PubMed:37248497
Research Area	Tumour  immunology  Signal transduction  G protein-coupled receptor  G protein signal
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human, Rat,  (predicted: Mouse, Dog, Cow, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	41kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human CCR3: 251-355/355
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	The protein encoded by this gene is a receptor for C-C type chemokines. It belongs to family 1 of the G protein-coupled receptors. This receptor binds and responds to a variety of chemokines, including eotaxin (CCL11), eotaxin-3 (CCL26), MCP-3(CCL7), MCP-4 (CCL13), and RANTES (CCL5). It is highly expressed in eosinophils and basophils, and is also detected in TH1 and TH2 cells, as well as in airway epithelial cells. This receptor may contribute to the accumulation and activation of eosinophils and other inflammatory cells in the allergic airway. It is also known to be an entry co-receptor for HIV-1. This gene and seven other chemokine receptor genes form a chemokine receptor gene cluster on the chromosomal region 3p21. Alternatively spliced transcript variants encoding the same protein have been described. Function: Receptor for a C-C type chemokine. Binds to eotaxin, eotaxin-3, MCP-3, MCP-4, RANTES and MIP-1 delta. Subsequently transduces a signal by increasing the intracellular calcium ions level. Alternative coreceptor with CD4 for HIV-1 infection. Subunit: Binds to HIV-1 Tat. Subcellular Location: Cell membrane; Multi-pass membrane protein. Tissue Specificity: In eosinophils as well as trace amounts in neutrophils and monocytes. Similarity: Belongs to the G-protein coupled receptor 1 family. SWISS: P51677 Gene ID: 1232 Database links: Entrez Gene: 1232 Human Entrez Gene: 12771 Mouse Entrez Gene: 117027 Rat Omim: 601268 Human SwissProt: P51677 Human SwissProt: P51678 Mouse SwissProt: O54814 Rat Unigene: 506190 Human Unigene: 57050 Mouse Unigene: 9890 Rat Chemokine受体3(CCR3)主要在嗜酸粒细胞，Th2lymphocyte，肥大细胞，支气管epithelial cells上表达， CCR3介导嗜酸粒细胞内有丝分裂原活化蛋白激酶（MAPK） 细胞外信号调节激酶-2（ERK2）、p38和JNK的活化。
Product Picture	Tissue/cell: human breast carcinoma; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; Incubation: Anti-CCR3 Polyclonal Antibody, Unconjugated(SL1167R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining Tissue/cell: rat colitis tissue; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; Incubation: Anti-CCR3 Polyclonal Antibody, Unconjugated(SL1167R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining

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