Product Name	Defensin beta 1
Chinese Name	防御素β1/Defensin β1抗体
Alias	BD 1; BD-1; BD1; beta 1; Beta defensin 1; Beta-defensin 1; DEFB 1; DEFB1; DEFB1_HUMAN; DEFB101; Defensin; Defensin beta 1 preproprotein; HBD 1; hBD-1; HBD1; MGC51822.
literatures	Specific References  (1)     |     SL1163R has been referenced in 1 publications. [IF=4.285] Sugiyama Makoto. et al. Vaginal mucus in mice: Developmental and gene expression features of epithelial mucous cells during pregnancy. Biol Reprod. 2021 Aug;:  IHC ;  Mouse.   PubMed:34416757
Research Area	Cell biology
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human, Mouse, Rat,
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	4.1/8kDa
Cellular localization	Secretory protein
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from rat Defensin Beta 1: 33-68/68
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Defensins form a family of microbicidal and cytotoxic peptides made by neutrophils. Members of the defensin family are highly similar in protein sequence. This gene encodes defensin, beta 1, an antimicrobial peptide implicated in the resistance of epithelial surfaces to microbial colonization. This gene maps in close proximity to defensin family member, defensin, alpha 1 and has been implicated in the pathogenesis of cystic fibrosis. The mature form of Beta defensin 1 is 36 amino acids. Function: Has bactericidal activity. Subcellular Location: Secreted. Tissue Specificity: Plasma. Similarity: Belongs to the beta-defensin family. SWISS: O89117 Gene ID: 64389 Database links: Entrez Gene: 1672 Human Entrez Gene: 64389 Rat Omim: 602056 Human SwissProt: P60022 Human Unigene: 32949 Human 防御素在动物体中广泛分布的，目前已知的α－防御素有6种，研究人员从动物体的肾脏、气管、鼻粘膜与唾液中也发现了两种β防御素，在许多器官的epithelial cells与非上皮组织的细胞中发现了β－防御素。防御素的表达与病原体的入侵是紧密相关。
Product Picture	Sample: Lane 1: Mouse trachea tissue lysates Lane 2: Mouse Kidney tissue lysates Lane 3: Rat trachea tissue lysates Lane 4: Rat Kidney tissue lysates Primary: Anti-Defensin beta 1 (SL1163R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 4.1/8 kDa Observed band size: 12 kDa Tissue/cell: rat kidney tissue; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; Incubation: Anti-beta Defensin 1 Polyclonal Antibody, Unconjugated(SL1163R) 1:400, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining Tissue/cell: human colon carcinoma; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; Incubation: Anti-Defensin β1 Polyclonal Antibody, Unconjugated(SL1163R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining Tissue/cell: rat kidney tissue; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; Incubation: Anti-Defensin β1 Polyclonal Antibody, Unconjugated(SL1163R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining

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