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Product Name APBB2 Chinese Name 铁蛋白Fe65样蛋白1抗体 Alias Amyloid beta (A4) precursor protein-binding, family B, member 2 (Fe65 like); Amyloid beta A4 precursor protein binding family B member 2; Amyloid beta A4 precursor protein-binding family B member 2; APBB 2; APBB2; APBB2_HUMAN; Fe65 like 1; Fe65 like; Fe65 like protein; FE65L 1; FE65L; FE65L1; Protein Fe65-like 1; Rirl 1; Rirl1; TR2 L; TR2L; Zfra; Zinc finger like protein. Research Area Cell biology Neurobiology Signal transduction Alzheimer's Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, ) Applications WB=1:500-2000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 83kDa Cellular localization The nucleus Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human APBB2: 251-350/758 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail The protein encoded by this gene interacts with the cytoplasmic domains of amyloid beta (A4) precursor protein and amyloid beta (A4) precursor-like protein 2. This protein contains two phosphotyrosine binding (PTB) domains, which are thought to function in signal transduction. Polymorphisms in this gene have been associated with Alzheimer's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
Function:
May modulate the internalization of beta-amyloid precursor protein.
Subunit:
Binds to the intracellular domain of the beta-amyloid precursor protein.
Similarity:
Contains 2 PID domains.
Contains 1 WW domain.
SWISS:
Q92870
Gene ID:
323
Database links:Entrez Gene: 323 Human
Entrez Gene: 11787 Mouse
Omim: 602710 Human
SwissProt: Q92870 Human
SwissProt: Q9DBR4 Mouse
Unigene: 479602 Human
Unigene: 482700 Mouse
Unigene: 5159 Mouse
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