TEL: +86 571 56623320 EMAIL: [email protected]
Product Name PIRT Chinese Name 磷酸肌醇相互作用蛋白抗体 Alias hCG_1776018; Phosphoinositide interacting regulator of transient receptor potential channels ; Phosphoinositide-interacting protein; Pirt; PIRT_HUMAN. Research Area Neurobiology Signal transduction Kinases and Phosphatases Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, Sheep, ) Applications ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 15kDa Cellular localization The cell membrane Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human PIRT: 51-137/137 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail PIRT is a 137 amino acid multi-pass membrane protein. Highly conserved among vertebrates, PIRT consists of two transmembrane domains and one putative C-terminal phosphoinositide-binding domain. Although PIRT is expressed in peripheral nervous system, with highest levels in dorsal root ganglion and trigeminal neurons, and lowest levels in sympathetic and enteric neurons, it is not expressed in spinal cord. PIRT is a required component of the VR1 complex, which positively regulates VR1, a sensor of both noxious heat and capsaicin. Correspondingly, PIRT knockout results in impaired responses to noxious heat and capsaicin exposure, while VR1 remains unaltered. The gene that encodes PIRT maps to human chromosome 17p13.1.
Function:
Regulatory subunit of TRPV1, a molecular sensor of noxious heat and capsaicin. Positively regulates TRPV1 channel activity via phosphatidylinositol-4,5-bisphosphate (PIP2). Binds various phosphoinositide, including phosphatidylinositol-4,5-bisphosphate (PIP2), but not phosphatidylinositol (PI).
Subunit:
Interacts with TRPV1
Subcellular Location:
Membrane; Multi-pass membrane protein
SWISS:
P0C851
Gene ID:
644139
Database links:Entrez Gene: 644139 Human
Omim: 612068 Human
SwissProt: P0C851 Human
Unigene: 553909 Human
Scan Wechat Qrcode