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Product Name Guanylin Chinese Name 鸟苷酸环化酶激活蛋白1抗体 Alias GapI; GCAP-I; Guanylate cyclase activating protein 1; Guanylate cyclase activator 2A (guanylin 2 intestinal heat-stable); Guanylate cyclase activator 2A; Guanylate cyclase-activating protein 1; Guanylate cyclase-activating protein I; Guanylin; GUC2A_HUMAN; GUCA 2; GUCA2; GUCA2A; STARA. Research Area Neurobiology Growth factors and hormones Kinases and Phosphatases Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Pig, Cow, Horse, Sheep, ) Applications ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 10kDa Cellular localization Secretory protein Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human Guanylin: 22-115/115 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail The family of guanylin regulatory peptides, including guanylin and uroguanylin, are strongly expressed in intestinal mucosa and regulate intestinal fluid secretion during digestion. Guanylins are also involved in acid neutralization and the regulation of membrane-bound guanylate cyclase signaling molecules. Guanylin and uroguanylin are secreted primarily in the stomach, intestine, and colon. Guanylin is also detected in plasma. Guanylin is an endogenous activator of intestinal guanylate cyclase. It stimulates intestinal guanylate cyclase through the same receptor binding region as the heat-stable enterotoxins. Gut enterochromaffin cells synthesize guanylin to be a prohormone of 115 amino acids which is then is processed to the molecular form of 94 amino acids. This 10kDa form is found circulating in the blood.
Function:
Endogenous activator of intestinal guanylate cyclase. It stimulates this enzyme through the same receptor binding region as the heat-stable enterotoxins.
Subcellular Location:
Secreted.
Tissue Specificity:
Highly expressed in ileum and colon. Found in plasma.
Similarity:
Belongs to the guanylin family.
SWISS:
Q02747
Gene ID:
2980
Database links:Entrez Gene: 2980 Human
Entrez Gene: 14915 Mouse
Omim: 139392 Human
SwissProt: Q02747 Human
SwissProt: P33680 Mouse
Unigene: 778 Human
Unigene: 2614 Mouse
Unigene: 11388 Rat
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