Product Name	TWSG1
Chinese Name	扭转原肠胚形成同源蛋白1抗体
Alias	PSEC0250; TSG; TSG1; twisted gastrulation homolog 1; Twisted gastrulation protein; TWSG1_HUMAN.
literatures	Specific References  (1)     |     SL11606R has been referenced in 1 publications. [IF=1.394] Liu Zhuohang. et al. Twisted gastrulation signaling modulator 1 promotes the ability of glioma cell through activating Akt pathway. Neuroreport. 2021 Feb;32(3):198-205  IHC ;  Human.   PubMed:33534374
Research Area	Cell biology  Neurobiology  Signal transduction
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Dog, Pig, Cow, Sheep, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	22kDa
Cellular localization	Secretory protein
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human TWSG1: 151-223/223
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Twisted Gastrulation Protein 1(TWSG1) is a secreted BMP binding protein structurally related to the BMP antagonists Chordin and Noggin. TSG can inhibit BMP activity by binding directly to BMP proteins thereby preventing BMPs from binding to their receptors. It can act either as a BMP4 agonist or antagonist (depending on the specific biochemical environment) by binding to the BMP4/Chordin complex. Function: May be involved in dorsoventral axis formation. Seems to antagonize BMP signaling by forming ternary complexes with CHRD and BMPs, thereby preventing BMPs from binding to their receptors. In addition to the anti-BMP function, also has pro-BMP activity, partly mediated by cleavage and degradation of CHRD, which releases BMPs from ternary complexes. May be an important modulator of BMP-regulated cartilage development and chondrocyte differentiation. May play a role in thymocyte development Subunit: nteracts with CHRD and BMP4. This interaction enhances CHRD/BMP4 complex formation. Interacts with BMP7 Subcellular Location: Secreted Similarity: Belongs to the twisted gastrulation protein family. SWISS: Q9GZX9 Gene ID: 57045 Database links: Entrez Gene: 57045 Human Entrez Gene: 705804 Rhesus monkey Omim: 605049 Human SwissProt: Q9GZX9 Human Unigene: 514685 Human

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