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Product Name Nicalin Chinese Name γ-分泌酶组件蛋白NCLN抗体 Alias NCLN; NCLN_HUMAN; NET59; Nicalin; Nicalin homolog (zebrafish); Nicastrin like protein; Nicastrin-like protein. Research Area Tumour Cell biology Neurobiology Signal transduction Growth factors and hormones transcriptional regulatory factor Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, ) Applications WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 59kDa Cellular localization cytoplasmic The cell membrane Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human Nicalin: 401-500/563 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail Nicastrin is an integral part of the Alzheimers associated gamma-secretase complex. Nicalin, a nicastrin-like protein, is not associated with gamma-secretase but rather interacts with NOMO (Nodal modulator). Nodals are TGF beta signaling factors that control various cell fate decisions during embryonic body planning stages in vertebrate development. The Nicalin/NOMO complex acts to regulate the nodal signaling factors during gastrulation. This regulation most often affects the development of the axial mesoderm. Nodal signaling is an important factor for melanoma cell invasiveness and tumorigenicity and inhibition of this signal can promote melanoma cells reverting back toward a melanocyte phenotype.
Function:
May antagonize Nodal signaling and subsequent organization of axial structures during mesodermal patterning.
Subunit:
Forms a complex with NOMO2 and TMEM147, resulting in a stabilization of the 3 proteins, which are otherwise quickly degraded by the proteasome. Due to the strong similarity between NOMO1, NOMO2 and NOMO3, probably also interacts with NOMO1 and NOMO3. Participates in a large protein complex, which is not related to the gamma-secretase complex.
Subcellular Location:
Endoplasmic reticulum membrane.
Tissue Specificity:
Highly expressed in pancreas and skeletal muscle and, at lower levels, in heart.
Similarity:
Belongs to the nicastrin family.
SWISS:
Q969V3
Gene ID:
56926
Database links:
Entrez Gene: 56926 HumanEntrez Gene: 103425 Mouse
Omim: 609156 Human
SwissProt: Q969V3 Human
SwissProt: Q8VCM8 Mouse
Unigene: 657032 Human
Unigene: 302791 Mouse
Unigene: 4202 Rat
Nicastrin(NCT)是高度糖基化的I型Transmembrane protein,是γ-分泌酶复合物的重要组件蛋白之一,广泛分布于人类或鼠的所有细胞类型。它不仅与γ-分泌酶的组装和成熟密切相关,其构象及表达变化对γ-分泌酶活性和阿尔茨海默病(Alzheimer's disease,AD)中β淀粉样蛋白(amyloid proteinβ,Aβ)的产生及降解也起重要调节作用。
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