Product Name	RAPGEF2
Chinese Name	Rap鸟嘌呤核苷酸交换因子2抗体
Alias	KIAA0313; Neural RAP guanine nucleotide exchange protein; nRap GEP; NRAPGEP; PDZ domain containing guanine nucleotide exchange factor 1; PDZ domain-containing guanine nucleotide exchange factor 1; PDZ GEF1; PDZ-GEF1; PDZGEF1; RA GEF; RA-GEF; Rap guanine nucleotide exchange factor 2; Rapgef2; RPGF2_HUMAN.
literatures	Specific References  (1)     |     SL11581R has been referenced in 1 publications. [IF=3.067] Ma X et al. MiR-486-5p-directed MAGI1/Rap1/RASSF5 signaling pathway contributes to hydroquinone-induced inhibition of erythroid differentiation in K562 cells. Toxicol In Vitro. 2020 Mar 19;66:104830.  WB ;  huamn.   PubMed:32198055
Research Area	Cell biology  Neurobiology  Signal transduction  G protein-coupled receptor  Exchange protein  G protein signal
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Rabbit, Sheep, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	167kDa
Cellular localization	cytoplasmic The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human RAPGEF2: 501-600/1499
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	SummaryMembers of the RAS (see HRAS; MIM 190020) subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RAPGEF2, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation (Rebhun et al., 2000 [PubMed 10934204]).[supplied by OMIM, Mar 2008] Function: Guanine nucleotide exchange factor (GEF) for Rap1A, Rap1B and Rap2B GTPases. Does not interact with cAMP or cGMP. Subunit: Interacts with MAGI2. Subcellular Location: Cell membrane (By similarity). Note=Associated with the synaptic plasma membrane Tissue Specificity: Highest expression levels in brain. Lower expression levels in heart, kidney, lung, and placenta. Post-translational modifications: Phosphorylation by PLK2 promotes its activity (By similarity). Phosphorylated upon DNA damage, probably by ATM or ATR. Similarity: Contains 1 cyclic nucleotide-binding domain. Contains 1 N-terminal Ras-GEF domain. Contains 1 PDZ (DHR) domain. Contains 1 Ras-associating domain. Contains 1 Ras-GEF domain. SWISS: Q9Y4G8 Gene ID: 9693 Database links: Entrez Gene: 9693 Human Omim: 609530 Human SwissProt: Q9Y4G8 Human Unigene: 723853 Human

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