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Product Name GNAT2 Chinese Name G蛋白转录因子α2/Gα t2抗体 Alias ACHM4; Cone type transducin alpha subunit; GNAT 2; GNAT C; Gnat2; GNAT2_HUMAN; GNATC; Guanine nucleotide binding protein (G protein) alpha transducing; polypeptide 2; Guanine nucleotide binding protein G t subunit alpha 2; Guanine nucleotide-binding protein G(t) subunit alpha-2; Transducin alpha 2; Transducin alpha-2 chain; Transducin alpha2; Transducin cone specific alpha polypeptide. Research Area Neurobiology Signal transduction G protein signal Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, ) Applications ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 40kDa Cellular localization The cell membrane Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human GNAT2: 2-100/354 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail Transducin is a 3-subunit guanine nucleotide-binding protein (G protein) which stimulates the coupling of rhodopsin and cGMP-phoshodiesterase during visual impulses. The transducin alpha subunits in rods and cones are encoded by separate genes. This gene encodes the alpha subunit in cones.
Function:
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Transducin is an amplifier and one of the transducers of a visual impulse that performs the coupling between rhodopsin and cGMP-phosphodiesterase.
Subunit:
G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.
Tissue Specificity:
Retinal rod outer segment.
DISEASE:
Defects in GNAT2 are the cause of achromatopsia type 4 (ACHM4) [MIM:139340]. Achromatopsia is an autosomal recessively inherited visual disorder that is present from birth and that features the absence of color discrimination.
Similarity:
Belongs to the G-alpha family. G(i/o/t/z) subfamily.
SWISS:
P19087
Gene ID:
2780
Database links:Entrez Gene: 2780 Human
Entrez Gene: 14686 Mouse
Omim: 139340 Human
SwissProt: P19087 Human
SwissProt: P50149 Mouse
Unigene: 36973 Human
Unigene: 439652 Mouse
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