Product Name	EN2
Chinese Name	同源盒蛋白转录因子EN2抗体
Alias	AUTS 1; AUTS1; EN 2; Engrailed 2; Engrailed homeo box 2; Engrailed homeobox 2; Engrailed homolog 2; Engrailed2; Homeobox protein engrailed 2; Homeobox protein engrailed2; Hu En 2; HuEn2; MabEn; HME2_HUMAN; Homeobox protein engrailed-2; Homeobox protein en-2; Hu-En-2.
Research Area	Cell biology  Neurobiology  Signal transduction  Stem cells  Epigenetics
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Mouse,  (predicted: Human, Rat, Dog, Pig, Sheep, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	34kDa
Cellular localization	The nucleus
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human EN2/Engrailed 2: 281-333/333
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Homeobox-containing genes are thought to have a role in controlling development. In Drosophila, the 'engrailed' (en) gene plays an important role during development in segmentation, where it is required for the formation of posterior compartments. Different mutations in the mouse homologs, En1 and En2, produced different developmental defects that frequently are lethal. The human engrailed homologs 1 and 2 encode homeodomain-containing proteins and have been implicated in the control of pattern formation during development of the central nervous system. [provided by RefSeq, Jul 2008]. Function: EN1 and EN2 encode homeodomain containing proteins and have been implicated in the control of pattern formation during development of the central nervous system. EN2 may play a role in susceptibility to autism spectrum disorders. Subcellular Location: Nuclear. DISEASE: Note=Genetic variations in EN2 may be associated with susceptibility to autism. Similarity: Belongs to the engrailed homeobox family. Contains 1 homeobox DNA-binding domain. SWISS: P19622 Gene ID: 2020 Database links: Entrez Gene: 2020 Human Entrez Gene: 13799 Mouse Entrez Gene: EN2 Rat Omim: 131310 Human SwissProt: Q05917 Chicken SwissProt: P19622 Human SwissProt: P09066 Mouse Unigene: 134989 Human Unigene: 4298 Mouse
Product Picture	Sample: Cerebrum (Mouse) Lysate at 40 ug Cerebellum (Mouse) Lysate at 40 ug Primary: Anti-EN2 (SL11552R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 34 kD Observed band size: 34 kD

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