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Rabbit Anti-FRA1 antibody
Rabbit Anti-FRA1 antibody
Fos related antigen 1; FOS like antigen 1; FOS L1; FOSL 1; Fos related antigen 1; Fos-related antigen 1; FOSL1; FOSL1 protein; FOSL1_HUMAN; FRA 1; FRA-1.
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  • NO.:SL1154R
    Clonality:Polyclonal
    Immunogen Species:Rabbit
    React Species:(predicted: Human,Mouse,Rat,)
    Applications:ELISA IHC-P IHC-F ICC IF
    concentration:1mg/ml
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Product Name FRA1
Chinese Name FRA-1蛋白抗体
Alias Fos related antigen 1; FOS like antigen 1; FOS L1; FOSL 1; Fos related antigen 1; Fos-related antigen 1; FOSL1; FOSL1 protein; FOSL1_HUMAN; FRA 1; FRA-1.  
Research Area Tumour  Cell biology  immunology  transcriptional regulatory factor  
Immunogen Species Rabbit
Clonality Polyclonal
React Species (predicted: Human, Mouse, Rat, )
Applications ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight 30kDa
Cellular localization The nucleus 
Form Liquid
Concentration 1mg/ml
immunogen KLH conjugated synthetic peptide derived from human FRA1: 101-200/271 
Lsotype IgG
Purification affinity purified by Protein A
Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
Product Detail The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. [provided by RefSeq].

Subunit:
Heterodimer.

Subcellular Location:
Nucleus.

Similarity:
Belongs to the bZIP family. Fos subfamily.
Contains 1 bZIP (basic-leucine zipper) domain.

SWISS:
P15407

Gene ID:
8061

Database links:

Entrez Gene: 8061 Human

Omim: 136515 Human

SwissProt: P15407 Human

Unigene: 283565 Human



FOSL1蛋白对cell factor、生长因子、感染或致癌刺激等生理或病理信号发生应答,调节基因的转录, 参与细胞的增殖、分化等过程. FOSL1在Tumour形成及发展过程中, 通过促进细胞增殖、抑制分化、促进Tumour细胞的侵袭和转移等过程发挥作用.

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