Product Name	ATPase Na+/ K+ beta 2
Chinese Name	钠钾ATP酶Channel protein抗体
Alias	adhesion molecule on glia; Na+K+ATPase; AMOG; AT1B2; AT1B2_HUMAN; ATP1B2; ATPase Na+/K+ transporting beta 2 polypeptide; ATPB2; ATPB2S; MGC93648; Na+/K+ -ATPase beta 2 subunit; Na, K ATPase beta 2 polypeptide; RATATPB2S; sodium potassium ATPase subunit beta 2 (non-catalytic); sodium pump subunit beta 2; sodium/potassium dependent ATPase beta 2 subunit; Sodium/potassium dependent ATPase subunit beta 2; sodium/potassium transporting ATPase beta 2 chain; sodium/potassium transporting ATPase subunit beta 2; Sodium/potassium-dependent ATPase subunit beta-2; Sodium/potassium-transporting ATPase subunit beta-2.
literatures	Specific References  (4)     |     SL1152R has been referenced in 4 publications. [IF=41.444] Sun, Zeguo. et al. LINE-1 promotes tumorigenicity and exacerbates tumor progression via stimulating metabolism reprogramming in non-small cell lung cancer. MOL CANCER. 2022 Dec;21(1):1-24  WB ;  Human.   PubMed:35842613 [IF=6.304] Shiman Zuo. et al. Establishment of a novel mesenchymal stem cell-based regimen for chronic myeloid leukemia differentiation therapy. Cell Death Dis. 2021 Feb;12(2):1-15  WB ;  Human.   PubMed:33627636 [IF=4.088] Yanhui Jia. et al. The deacetylation of Akt by SIRT1 inhibits inflammation in macrophages and protects against sepsis. EXP BIOL MED. ;():  WB ;  Human,Mouse.   PubMed:37211747 [IF=1.689] Wang HY et al. Occludin Endocytosis is Involved in Disruption of the Intestinal Epithelial Barrier in a Mouse Model of Alcoholic Steatohepatitis. J Dig Dis. 2019 Jul 12.  WB ;  Human.   PubMed:31298798
Research Area	Channel protein  glycoprotein
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human, Mouse,  (predicted: Rat, Pig, Cow, Horse, Rabbit, Guinea Pig, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 ICC=1:100-500 IF=1:100-500  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	33kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human ATP1b2: 201-290/290 <Extracellular>
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	The protein encoded by this gene belongs to the family of Na+/K+ and H+/K+ ATPases beta chain proteins, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. The glycoprotein subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes a beta 2 subunit. [provided by RefSeq, Jul 2008] Function: This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The exact function of the beta-2 subunit is not known. Subunit: Composed of three subunits: alpha (catalytic), beta and gamma. Subcellular Location: Membrane; Single-pass type II membrane protein. Similarity: Belongs to the X(+)/potassium ATPases subunit beta family. SWISS: P14415 Gene ID: 482 Database links: Entrez Gene: 482 Human Omim: 182331 Human SwissProt: P14415 Human Unigene: 643540 Human Channel protein（Channel Protein） 钠钾ATP酶是位于The cell membrane上的一种glycoprotein,与ATP 的分解和细胞内外钠、钾离子的转运密切相关,哺乳动物各种组织细胞的钠钾ATP 酶的immunology特性基本相同。
Product Picture	Sample: Lane 1: Mouse Cerebrum tissue lysates Lane 2: Human K562 cell lysates Lane 3: Human SH-SY5Y cell lysates Primary: Anti-ATPase Na+/ K+ beta 2 (SL1152R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 33 kDa Observed band size: 60 kDa Tissue/cell: human kidney tissue; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; Incubation: Anti-AMOG Polyclonal Antibody, Unconjugated(SL1152R) 1:500, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining Tissue/cell: mouse colon tissue; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; Incubation: Anti-ATP1b2/Na+K+ATPase Polyclonal Antibody, Unconjugated(SL1152R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining

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