Product Name	FOXD3
Chinese Name	叉头蛋白D3抗体
Alias	AIS1; forkhead box D3; Forkhead box protein D3; FOXD3_HUMAN
literatures	Specific References  (1)     |     SL11518R has been referenced in 1 publications. [IF=2.688] Wang,et al.FOXD3/FOXD4 is required for the development of hindgut in the rat model of anorectal malformation.(2018) Experimental Biology and Medicine. 243:327-333.  IHC-P ;  Rat.   PubMed:29307282
Research Area	Tumour  Cell biology  Neurobiology  Signal transduction  Stem cells  transcriptional regulatory factor
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Chicken, Dog, Cow, Rabbit, )
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	48kDa
Cellular localization	The nucleus
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human FOXD3: 151-230/478
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Embryonic stem cells require the forkhead transcriptional regulator FoxD3 for survival. Following gastrulation, FoxD3 generally gets downregulated, except in the neural crest. A variety of growth factors induce FoxD3 expression, including FGF8 and SNAIL, maintaining the effected cells in an undifferentiated state. Thus defects in FoxD3 induction may cause premature differentiation and/or migration-asociated birth defects. Function: Binds to the consensus sequence 5'-A[AT]T[AG]TTTGTTT-3' and acts as a transcriptional repressor. Also acts as a transcriptional activator. Promotes development of neural crest cells from neural tube progenitors. Restricts neural progenitor cells to the neural crest lineage while suppressing interneuron differentiation. Required for maintenance of pluripotent cells in the pre-implantation and peri-implantation stages of embryogenesis. Subcellular Location: Nucleus. Tissue Specificity: Expressed in chronic myeloid leukemia, Jurkat T-cell leukemia and teratocarcinoma cell lines, but not in any other cell lines or normal tissues examined. DISEASE: Defects in FOXD3 are associated with susceptibility to autoimmune disease type 1 (AIS1) [MIM:607836]. AIS1 is a disorder characterized by the association of vitiligo with autoimmune thyroiditis (Hashimoto thyroiditis). Similarity: Contains 1 fork-head DNA-binding domain. SWISS: P19099 Gene ID: 27022 Database links: Entrez Gene: 27022 Human Entrez Gene: 15221 Mouse Omim: 611539 Human SwissProt: Q9UJU5 Human SwissProt: Q61060 Mouse Unigene: 546573 Human Unigene: 4758 Mouse

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