Product Name	FADS2
Chinese Name	脂肪酸脱氢酶2抗体
Alias	D6D; Delta(6) desaturase; Delta(6) fatty acid desaturase; DES 6; DES6; FADS 2; FADSD 6; FADSD6; Fatty acid desaturase 2; linoleoyl-CoA desaturase (delta-6-desaturase) like 2; LLCDL 2; LLCDL2; SLL0262; TU 13; TU13; FADS2_HUMAN.
literatures	Specific References  (2)     |     SL11516R has been referenced in 2 publications. [IF=3.701] Xiaoxia Liu. et al. EGCG regulates fatty acid metabolism of high-fat diet-fed mice in association with enrichment of gut Akkermansia muciniphila. J Funct Foods. 2020 Dec;75:104261  IHC ;  Mouse.   PubMed:10.1016/j.jff.2020.104261 [IF=2.752] Xuchun Liu. et al. The Effect of FATP1 on Adipocyte Differentiation in Qinchuan Beef Cattle. Animals-Basel. 2021 Oct;11(10):2789  WB ;  Bovine.   PubMed:10.3390/ani11102789
Research Area	Tumour  Cardiovascular  immunology  Neurobiology  Kinases and Phosphatases
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Mouse,  (predicted: Human, Rat, Chicken, Pig, Cow, Horse, Rabbit, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	52kDa
Cellular localization	cytoplasmic The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human FADS2: 221-300/444
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Members of the fatty acid desaturase (FADS) family, including FADS1, FADS2 and FADS3, regulate the desaturation of fatty acids by introducing double bonds between defined carbons of fatty acyl chains, thereby playing an essential role in the lipid metabolic pathway. Members of this family share N-terminal cytochrome b5-like domains, C-terminal multiple membrane-spanning desaturase regions and 3 histidine box motifs. FADS2 (fatty acid desaturase 2), also known as D6D, DES6, LLCDL2 or TU13, is a 444 amino acid multi-pass membrane protein that localizes to the endoplasmic reticulum and contains one cytochrome b5 heme-binding domain. Expressed in adult and fetal heart and in adult liver, brain, lung and retina, FADS2 functions as a component of a lipid metabolic pathway and catalyzes the first step in the pathway, namely the formation of unsaturated fatty acids from polyunsaturated fatty acids. Defects in the gene encoding FADS2 are the cause of cause of fatty acid delta-6-desaturase deficiency, an affliction that is characterized by skin abnormalities, corneal ulceration and growth failure. Multiple isoforms of FADS2 exist due to alternative splicing events. Function: FADS2 (Fatty acid desaturase 2) catalyses the biosynthesis of highly unsaturated fatty acids from precursor essential polyunsaturated fatty acids (linoleic and alpha-linoleic acid). FADS family members comprise an N-terminal cytochrome b5-like domain and a C-terminal membrane-spanning desaturase. FADS2 is repressed by dietary highly unsaturated fatty acids. Altered expression of FADS2 may be associated with obesity-associated insulin resistance. Genetic studies have linked FADS2 to IQ and attention-deficit/hyperactivity disorder (ADHD). Subcellular Location: Endoplasmic reticulum membrane; Multi-pass membrane protein Tissue Specificity: Expressed in a wide array of tissues, highest expression is found in liver followed by brain, lung, heart, and retina. A lower level is found in breast tumor when compared with normal tissues; lowest levels were found in patients with poor prognostic index. Similarity: Belongs to the fatty acid desaturase family. Contains 1 cytochrome b5 heme-binding domain. SWISS: O95864 Gene ID: 9415 Database links: Entrez Gene: 9415 Human Entrez Gene: 56473 Mouse Entrez Gene: 83512 Rat Omim: 606149 Human SwissProt: Q4R749 Cynomolgus monkey SwissProt: O95864 Human SwissProt: Q9Z0R9 Mouse SwissProt: Q5REA7 Orangutan SwissProt: Q9Z122 Rat Unigene: 502745 Human Unigene: 38901 Mouse Unigene: 162483 Rat
Product Picture	Sample: Lane 1: Mouse Cerebrum tissue lysates Lane 2: Mouse Heart tissue lysates Primary: Anti-FADS2 (SL11516R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 52 kDa Observed band size: 47 kDa

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