Product Name	ATRNL1
Chinese Name	ATRNL1蛋白抗体
Alias	ATRN1_HUMAN; ATRNL1; Attractin-like protein 1; KIAA0534.
Research Area	Cell biology  Neurobiology  Signal transduction  The cell membrane受体  G protein-coupled receptor  G protein signal
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep, )
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	147kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human ATRNL1: 501-600/1379 <Extracellular>
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	ATRNL1 is a 1,379 amino acid single-pass type I membrane protein that may play a role in melanocortin signaling pathways that regulate energy homeostasis. The ATRNL1 protein contains a C-type lectin domain, a CUB domain, two EGF-like domains, six Kelch repeats, two laminin EGF-like domains and five PSI domains. ATRNL1 interacts with MC4-R in several regions known to be important in the regulation of energy homeostasis by melanocortins, such as the paraventricular nucleus of hypothalamus and the dorsal motor nucleus of the vagus. The ATRNL1 gene is conserved in dog, cow, mouse, rat, chicken, zebrafish and C. elegans, exists as two alternatively spliced isoforms and maps to human chromosome 10q25.3. Strong evidence of linkage to late-onset Alzheimer disease (LOAD) is linked to chromosome 10, which implicates a wide region and at least one disease-susceptibility locus. Function: May play a role in melanocortin signaling pathways that regulate energy homeostasis. Subunit: Interacts with MC4R Subcellular Location: Membrane; Single-pass type I membrane protein Similarity: Contains 1 C-type lectin domain. Contains 1 CUB domain. Contains 2 EGF-like domains. Contains 6 Kelch repeats. Contains 2 laminin EGF-like domains. Contains 5 PSI domains. SWISS: Q5VV63 Gene ID: 26033 Database links: Entrez Gene: 26033 Human Omim: 612869 Human SwissProt: Q5VV63 Human Unigene: 501127 Human

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