Product Name	UNC5D
Chinese Name	神经突起生长诱导因子受体UNC5D抗体
Alias	UNC5H4; UNC5D; Netrin receptor UNC5D; Netrin receptor Unc5h4; Protein unc 5 homolog D; Unc 5 homolog 4; Unc 5 homolog D (C. elegans); Unc 5 homolog D; UNC 5D; Unc5h4; FLJ16019; KIAA1777.
literatures	Specific References  (1)     |     SL11494R has been referenced in 1 publications. [IF=6.684] Aditi Karmakar. et al. Identification of Epigenetically Modified Hub Genes and Altered Pathways Associated With Retinoblastoma. Front Cell Dev Biol. 2022; 10: 743224  WB ;  Human.   PubMed:35359459
Research Area	Cell biology  Neurobiology
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	102kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human UNC5H4: 112-200/953 <Extracellular>
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	The UNC5H family of proteins act as transmembrane receptors for netrin-1 and play a crucial role in axon guidance and migration of neural cells. Additionally, when cleaved by a caspase to produce an intracellular fragment containing a death domain,UNC5H receptors induce apoptosis. This activity is blocked by the binding of netrin-1. In the absence of netrin-1, UNC5H receptors act as tumor suppressors by inhibiting anchorage-independent growth and invasion, but mutation of these receptors provides a potential mechanism for tumorigenicity. The expression of UNC5H receptors is down-regulated in multiple carcinomas, including colorectal, breast, ovary, uterus, stomach, lung, and kidney cancers. UNC5H4, also known as UNC5D (unc-5 homolog D), is single-pass type I membrane protein that is a member of the UNC5H netrin receptor family. Two isoforms of UNC5H4 exist due to alternative splicing events. Function: UNC5D belongs to a family of netrin 1 receptors thought to mediate the chemorepulsive effect of netrin 1 on specific axons. On ligand binding UNC5D may mediate axon repulsion of neuronal growth cones in the developing nervous system. Subunit: Interacts with the cytoplasmic part of DCC Subcellular Location: Membrane; Single-pass type I membrane protein. Post-translational modifications: Phosphorylated on cytoplasmic tyrosine residues (By similarity). Proteolytically cleaved by caspases during apoptosis. The cleavage does not take place when the receptor is associated with netrin ligand. Its cleavage by caspases is required to induce apoptosis Similarity: Belongs to the unc-5 family. Contains 1 death domain. Contains 1 Ig-like (immunoglobulin-like) domain. Contains 1 Ig-like C2-type (immunoglobulin-like) domain. Contains 2 TSP type-1 domains. Contains 1 ZU5 domain. SWISS: Q6UXZ4 Gene ID: 137970 Database links: Entrez Gene: 137970 Human SwissProt: Q6UXZ4 Human Unigene: 238889 Human

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