Product Name	Semaphorin 5B
Chinese Name	Transmembrane proteinSEMA5B抗体
Alias	SEM5B_HUMAN; SEMA5B; SEMAG; Semaphorin-5B; Semaphorin 5B; Semaphorin5B; SemG.
Research Area	Developmental biology  Neurobiology  Signal transduction
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Mouse,  (predicted: Human, Rat, Chicken, Dog, Cow, Horse, Sheep, )
Applications	WB=1:500-2000 ELISA=1:5000-10000  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	126kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human SEMA5B/Semaphorin 5B: 146-195/1151 <Extracellular>
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Semaphorins are a family of cell surface and secreted proteins that are conserved from insects to humans. Members of this family of proteins are approximately 750 amino acids in length (including signal sequences) and are defined by a conserved extracellular “semaphorin” domain of approximately 500 amino acids containing 14-16 cysteines, blocks of conserved sequences and no obvious repeats. Secreted and cell-bound semaphorins chemically attract and repel the growth of neural axons, guiding the development of intricate networks of neural tissue. SEMA5B (semaphorin-5B), also known as SEMAG, is a 1151 amino acid member of the semaphorin family. Localized to the membrane, SEMA5B is a single-pass type III protein that functions to convey positive axonal guidance cues and can induce calpain-mediated cleavage of calcineurin. Three isoforms exist due to alternative splicing events. Function: May act as positive axonal guidance cues. Subcellular Location: Membrane; Single-pass type III membrane protein. Similarity: Belongs to the semaphorin family. Contains 1 PSI domain. Contains 1 Sema domain. Contains 5 TSP type-1 domains. SWISS: Q9P283 Gene ID: 54437 Database links: Entrez Gene: 54437 Human Omim: 609298 Human SwissProt: Q9P283 Human Unigene: 210870 Human
Product Picture	Sample: Testis (Mouse) Lysate at 40 ug Cerebellum (Mouse) Lysate at 40 ug Primary: Anti-Semaphorin 5B (SL11482R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 126 kD Observed band size: 126/150 kD

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