Product Name	GDF7
Chinese Name	生长分化因子7抗体
Alias	bmp12; bone morphogenetic protein 12; GDF-7; Gdf 7; GDF7_HUMAN; growth differentiation factor 7; Growth/differentiation factor 7.
literatures	Specific References  (1)     |     SL11461R has been referenced in 1 publications. [IF=4.522] Wang Y et al. Aspirin promotes tenogenic differentiation of tendon stem cells and facilitates tendinopathy healing through regulating the GDF7/Smad1/5 signaling pathway. J Cell Physiol. 2019 Oct 21.  WB ;  Rat.   PubMed:31637734
Research Area	Cell biology  Neurobiology  Signal transduction  Stem cells  Growth factors and hormones  transcriptional regulatory factor
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Chicken, Pig, Cow, Horse, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	14kDa
Cellular localization	Secretory protein
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human GDF7: 362-410/450
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Growth/differentiation factors (GDFs) are members of the TGF superfamily (1,2). Members of the TGF superfamily are involved in embryonic development and adult tissue homeostasis (1). GDF-1 expression is almost exclusively restricted to the central nervous system and mediates cell differentiation events during embryonic development (3). Neither GDF-3 (Vgr-2) nor GDF-9 contains the conserved cysteine residue which is found in most other TGF superfamily members. GDF-3 is detectable in bone marrow, spleen, thymus and adipose tissue, whereas GDF-9 has only been detected in ovary (4). GDF-5 (also designated CDMP-1) has been shown to induce activation of plasminogen activator, thereby inducing angiogenesis. It is predominantly expressed in long bones during fetal embryonic development and is involved in bone formation. (5). GDF-5 mutations have been identified in mice with the mutation brachypodism (bp), a mutation which affects the length and number of bones in limbs (6). GDF-6 and GDF-7 are closely related to GDF-5 (6). GDF-8 has been shown to be a negative regulator of skeletal muscle mass (1). Function: May play an active role in the motor area of the primate neocortex. Subunit: Homodimer; disulfide-linked Subcellular Location: Secreted. Similarity: Belongs to the TGF-beta family. SWISS: Q7Z4P5 Gene ID: 151449 Database links: Entrez Gene: 151449 Human Entrez Gene: 238057 Mouse Entrez Gene: 252833 Rat Omim: 604651 Human SwissProt: Q7Z4P5 Human SwissProt: P43029 Mouse Unigene: 447688 Human Unigene: 271308 Mouse Unigene: 92437 Rat

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