Product Name	ARF6
Chinese Name	ADP核糖基化因子6抗体
Alias	ADP ribosylation factor 6; ADP ribosylation factor protein 6; ADP-ribosylation factor 6; Small GTPase; AI788669; AW496366; MGC102530; ADP ribosylation factor protein 6; ARF6_HUMAN; DKFZp564M0264; Small GTP binding protein.
Research Area	Signal transduction
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Chicken, Pig, Horse, Rabbit, )
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	20kDa
Cellular localization	cytoplasmic The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human ARF6: 101-175/175
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	This gene encodes a member of the human ARF gene family, which is part of the RAS superfamily. The ARF genes encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking and as activators of phospholipase D. The product of this gene is localized to the plasma membrane, and regulates vesicular trafficking, remodelling of membrane lipids, and signaling pathways that lead to actin remodeling. A pseudogene of this gene is located on chromosome 7. Function: GTP-binding protein involved in protein trafficking; regulates endocytic recycling and cytoskeleton remodeling. May modulate vesicle budding and uncoating within the Golgi apparatus. Functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in the regulation of dendritic spine development. Contributes to the regulation of dendritic branching and filopodia extension. Subunit: Interacts with ARHGAP21, ASAP2, HERC1, PIP5K1C and UACA. Interacts with NCS1/FREQ at the plasma membrane. Interacts with RAB11FIP3 and RAB11FIP4. Interacts with USP6 (via Rab-GAP TBC domain). Interacts with ECM29. Interacts with TBC1D24. Subcellular Location: Golgi apparatus. Cell membrane; Lipid-anchor. Endosome membrane; Lipid-anchor. Cell membrane. Cell projection, filopodium membrane; Lipid-anchor. Note=Recruited to the cell membrane in association with CYTH2 and ARL4C. Similarity: Belongs to the small GTPase superfamily. Arf family. SWISS: P62330 Gene ID: 382 Database links: Entrez Gene: 382 Human Entrez Gene: 11845 Mouse Entrez Gene: 780425 Pig Entrez Gene: 79121 Rat Omim: 600464 Human SwissProt: P26990 Chicken SwissProt: P62330 Human SwissProt: P62331 Mouse SwissProt: Q007T5 Pig SwissProt: P62332 Rat Unigene: 525330 Human Unigene: 719973 Human Unigene: 27308 Mouse Unigene: 6993 Rat ARF6主要用于：Tumour方面的研究，在很多Tumour组织中都有一定的表达及分布。 技术背景：rRNA 加工、内质网高尔基膜泡介导运输、细胞运动性、细胞附着、小GTP 酶介导Signal transduction、蛋白运输、膜泡介导运输、正调控肌动蛋白丝聚合、皮层肌动蛋白Cytoskeleton组织和生物发生、褶边组织和生物发生、调控Rac 蛋白Signal transduction、负调控受体介导胞吞.

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