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Product Name PHF21A Chinese Name PHD指蛋白21A抗体 Alias BHC80 / PHF21A; BHC80a; BM-006; BRAF35-HDAC complex protein BHC80; BRAF35-HDAC complex protein BHC80; BRAF35-HDAC complex protein BHC80; BRAF35/HDAC2 complex (80 kDa); KIAA1696; PF21A_HUMAN; PHD finger protein 21A; PHF21A. Research Area Neurobiology transcriptional regulatory factor Zinc finger protein Epigenetics Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep, ) Applications ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 75kDa Cellular localization The nucleus Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human PHF21A: 351-450/680 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail The PHF21A gene encodes BHC80, a component of a BRAF35 (MIM 605535)/histone deacetylase (HDAC; see MIM 601241) complex (BHC) that mediates repression of neuron-specific genes through the cis-regulatory element known as repressor element-1 (RE1) or neural restrictive silencer (NRS) (Hakimi et al., 2002 [PubMed 12032298]).[supplied by OMIM, Nov 2010]
Function:
Component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it may act as a scaffold. Inhibits KDM1A-mediated demethylation of 'Lys-4' of histone H3 in vitro, suggesting a role in demethylation regulation.
Subunit:
Component of a BHC histone deacetylase complex that contains HDAC1, HDAC2, HMG20B/BRAF35, KDM1A, RCOR1/CoREST and PHF21A/BHC80. The BHC complex may also contain ZMYM2, ZNF217, ZMYM3, GSE1 and GTF2I. In the complex, it interacts directly with HDAC1, HDAC2, HMG20B/BRAF35, KDM1A and RCOR1/CoREST.
Subcellular Location:
Nucleus.
Tissue Specificity:
Highly expressed in brain. Expressed at much lower level in other tissues.
Similarity:
Contains 1 A.T hook DNA-binding domain.
Contains 1 PHD-type zinc finger.
SWISS:
Q96BD5
Gene ID:
51317
Database links:Entrez Gene: 51317 Human
Entrez Gene: 192285 Mouse
SwissProt: Q96BD5 Human
SwissProt: Q6ZPK0 Mouse
Unigene: 502458 Human
Unigene: 330408 Mouse
Unigene: 450689 Mouse
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